Evidence map›Paper›PMID 41201561›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

From clinic to couch: a pilot study of home-use photobiomodulation for radiation-induced oral mucositis and dermatitis.

Saeed Salman, Ragda Abdalla-Aslan, Ahmad Awawdi, Rana Tarabeih, Salem Billan

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05176834 (Self-applied Photobiomodulation Therapy With a Home-use Device for the Prevention and/or Acceleration of Healing of Radiation-induced Oral Mucositis in Patients With Head and Neck Malignancies - A Feasibility Study), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05176834 naunknown statusnot on this map

Self-applied Photobiomodulation Therapy With a Home-use Device for the Prevention and/or Acceleration of Healing of Radiation-induced Oral Mucositis in Patients With Head and Neck Malignancies - A Feasibility Study

TypeinterventionalSponsorErika Carmel ltdRan2022 to 2023Enrolled20ConditionsMucositis, Head and Neck Cancer, Radiotherapy Side EffectArmsB-Cure laser pro
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saeed Salman *Fishman Oncology Center, Rambam Health Care Campus, Haifa, Israel. saeed.salman@technion.ac.il.
Ragda Abdalla-Aslan *Oral and Maxillofacial Surgery Department, Rambam Health Care Campus, Haifa, Israel.
Ahmad AwawdiFishman Oncology Center, Rambam Health Care Campus, Haifa, Israel.
Rana TarabeihFishman Oncology Center, Rambam Health Care Campus, Haifa, Israel.
Salem BillanFishman Oncology Center, Rambam Health Care Campus, Haifa, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRadiation-induced oral mucositis (OM) and dermatitis (RD) are common debilitating toxicities of radiotherapy (RT) for head and neck cancer (HNC) patients. While photobiomodulation (PBM) has shown promise in reducing severity of these adverse effects, in-clinic treatments pose logistic and financial challenges. This study assessed the feasibility and compliance of a home-use, self-applied near-infrared PBM device for the prevention and treatment of RT-induced OM and RD.

methodsThis prospective, single-arm trial enrolled 20 HNC patients scheduled for intensity-modulated RT (IMRT) with or without concurrent chemotherapy. Seventeen patients were analyzed following exclusions. Participants self-administered PBM at home twice daily for 9-11 weeks, from RT initiation to four weeks post-RT. The primary outcome was compliance (≥ 50% of expected treatments). Secondary outcomes included incidence of severe (grade 3-4) OM and RD.

results67% of the participants completed at least 50% of the prescribed PBM treatments. Overall, 60% of expected sessions were administered, surpassing the predefined compliance threshold. By week 3, 6% presented with severe OM and none with severe RD. At RT completion, 41% and 18% had severe OM and RD, respectively. Four weeks post-RT, no severe OM or RD were observed, with the majority presenting with no toxicity (grade 0). No device related adverse effects were reported, and patients reported high comfort and ease of use.

conclusionSelf-administered, home-use PBM is a feasible and well-tolerated approach that shows promise as pre-emptive treatment for RT induced OM and RD. Large-scale, randomized, placebo-controlled trials are needed to confirm these findings and evaluate long-term benefits.

trial registrationClinicalTrials.gov Identifier: NCT05176834. Registration Date: December 13th, 2021.

Indexed as

Head and Neck NeoplasmsLow-Level Light TherapyRadiation InjuriesRadiodermatitisStomatitisAdultAgedFeasibility StudiesFemaleHumansMaleMiddle AgedPatient CompliancePilot ProjectsProspective StudiesRadiotherapy, Intensity-ModulatedHead and neck neoplasmsIntensity-modulated radiotherapyLow-level laser therapyOral mucositisPhotobiomodulation therapyRadiation-induced dermatitis

Identifiers

PMID41201561
PMCPMC12594705

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Registered trials

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