Evidence map›Paper›PMID 41201549›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2026

Clinical course of chest pain associated with esophageal motility disorders following peroral endoscopic myotomy.

Shinya Hoki, Hirofumi Abe, Shinwa Tanaka, Hiroshi Tanabe, Eri Nishikawa, Hitomi Hori, Tatsuya Nakai, Chise Ueda, Satoshi Urakami, Masato Kinoshita and 5 more

Abstract read
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In one paragraph

Article in Esophagus : official journal of the Japan Esophageal Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Shinya HokiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Hirofumi AbeDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan. abe627@med.kobe-u.ac.jp.ORCID 0000-0002-1938-330X
Shinwa TanakaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Hiroshi TanabeDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Eri NishikawaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Hitomi HoriDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Tatsuya NakaiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Chise UedaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Satoshi UrakamiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Masato KinoshitaDepartment of Gastroenterology, Konan Medical Center, Kobe, Japan.
Hiroya SakaguchiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Tetsuya YoshizakiDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Fumiaki KawaraDepartment of Gastroenterology, Konan Medical Center, Kobe, Japan.
Takashi ToyonagaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.
Yuzo KodamaDivision of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-Cho, Chuo-Ku, Kobe, Hyogo, 650-0017, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsChest pain affects the quality of life of patients with esophageal motility disorders (EMD). However, the natural course of EMD-related chest pain following treatment remains unclear. We aimed to elucidate the clinical course of EMD-related chest pain following peroral endoscopic myotomy (POEM).

methodsPatients who underwent POEM for EMD between April 2016 and March 2022 were enrolled. Patients under 18 years, those without chest pain before POEM, and those without a 1-year follow-up were excluded. The frequency and intensity of chest pain were recorded annually according to the chest pain component of the Eckardt score and the numerical rating scale (NRS). Meaningful improvement was defined as a ≥ 1-point reduction in the chest pain component of the Eckardt score, and independently, as a ≥ 2-point reduction on the NRS. Clinical improvement in chest pain was defined as a meaningful improvement in either the chest pain frequency or intensity.

resultsIn total, 168 patients were included in this study. The scores for chest pain intensity and frequency were reduced to 32% and 42% of preoperative values at 5 years after POEM. At 1 and 5 years after POEM, meaningful improvements in frequency were observed in 77% and 60% of patients, and in intensity in 92% and 81%, respectively. Clinical improvement in chest pain rate was 96% at 1 year and 87% at 5 years after POEM.

conclusionsPOEM was effective in treating EMD-related chest pain, particularly in terms of intensity.

Indexed as

Chest PainEsophageal Motility DisordersEsophagoscopyMyotomyNatural Orifice Endoscopic SurgeryAdultAgedFemaleHumansMaleMiddle AgedPain MeasurementQuality of LifeTreatment OutcomeAchalasiaChest painEsophageal motility disordersMyotomyPain intensity

Identifiers

PMID41201549

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.