ArticleJournal of gastrointestinal cancer2025
Exploring Recurrence Patterns of Esophageal Carcinoma Post-Curative Resection: a Comprehensive Study from a High-Volume Oncology Center in India.
Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCarcinoma esophagus is an aggressive malignancy with high recurrence rates even after curative resection. This study aimed to evaluate recurrence patterns-both locoregional and systemic-after curative esophagectomy and to identify clinical and pathological predictors of recurrence to guide post-treatment surveillance and therapeutic strategies.
methodsThis retrospective study of a prospectively maintained database included 314 patients with carcinoma esophagus who underwent curative esophagectomy at a tertiary oncology center in India between January 2012 and January 2020. Clinical, pathological, and treatment-related parameters were analyzed. Recurrence patterns and survival outcomes were evaluated. Statistical analysis was performed using SPSS version 29, with univariate and multivariate analyses to determine prognostic factors for recurrence.
resultsThe study included 314 patients, with a mean age of 54 years (range 22-82 years); the most common presenting symptom was dysphagia (92.0%), followed by anorexia (18.5%) and vomiting (10.5%). The overall recurrence rate was 30.9%, with systemic recurrence being the most common (12.1%), followed by locoregional (8.0%) and combined recurrences (10.8%). The liver (47%), lungs (34%), and mediastinal nodes (30%) were the most frequent sites of recurrence. Median survival post-recurrence was 9.13 months for locoregional, 7.53 months for systemic, and 5.2 months for combined recurrence. Univariate analysis revealed significant associations with smoking, alcohol use, tumor length, and lymphovascular invasion. Multivariate analysis identified poor response to neoadjuvant therapy, perineural invasion, and advanced disease stage as independent predictors of recurrence.
conclusionRecurrence after curative esophagectomy is driven by multiple factors, including tumor biology and treatment response. Identifying high-risk patients based on response to neoadjuvant therapy and pathological features can inform tailored surveillance and treatment approaches to improve patient outcomes.
Indexed as
Identifiers
41201534What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.