Evidence map›Paper›PMID 41201383›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2025

Combinatorial Analyses of Pre-mRNA Splicing-Defective Mutants Reveal Differential Quantitative Requirements for Shelterin in Distinct Telomere Functions.

Miho Takeuchi, Yoko Otsubo, Junko Kanoh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Miho TakeuchiInstitute for Protein Research, Osaka University, Suita, Osaka, Japan.
Yoko OtsuboLife Science Network, The University of Tokyo, Meguro-ku, Tokyo, Japan.ORCID https://orcid.org/0000-0002-2401-4808
Junko KanohInstitute for Protein Research, Osaka University, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0002-8889-033X

Funding

Daiichi Sankyo Foundation of Life ScienceJapan Society for the Promotion of Science JP17H03606Japan Society for the Promotion of Science JP21H00244Japan Society for the Promotion of Science JP22H04685Japan Society for the Promotion of Science JP23H02408Ohsumi Frontier Science FoundationTakeda Science Foundation
6 · The paper itself

Abstract

Telomeres perform multiple functions to maintain genome stability, including telomere length regulation, chromosome end protection, and meiotic chromosome dynamics. These functions are governed by shelterin, a telomere-binding protein complex. Here, we show that Tls1 and Cay1 act at distinct steps in pre-mRNA splicing, specifically ensuring sufficient protein levels of Schizosaccharomyces pombe shelterin components Rap1 and Poz1, which are critical for telomere maintenance. Accordingly, deletion of tls1

Indexed as

RNA PrecursorsRNA SplicingSchizosaccharomycesSchizosaccharomyces pombe ProteinsTelomereTelomere-Binding ProteinsMeiosisMutationShelterin ComplexTelomere HomeostasisPoz1 protein, S pombeRap1 protein, S pombeRNA PrecursorsSchizosaccharomyces pombe ProteinsShelterin ComplexTelomere-Binding Proteinschromosomemeiosispre‐mRNA splicingtelomere

Identifiers

PMID41201383
PMCPMC12594046

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.