Evidence map›Paper›PMID 41201234›Full record

ReviewImmunological reviews2025

Functional Specialization and Collaboration of cDC2 Subsets in CD4+ T Cell Priming and Differentiation.

Naoya Tatsumi, Ariel Tjitropranoto, Alejandro Davila-Pagan, Yosuke Kumamoto

Abstract readReview
In one paragraph

Review in Immunological reviews, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Naoya TatsumiCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Ariel TjitropranotoCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Alejandro Davila-PaganCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.
Yosuke KumamotoCenter for Immunity and Inflammation, Rutgers New Jersey Medical School, Newark, New Jersey, USA.ORCID https://orcid.org/0000-0001-9369-4934

Funding

Regulation of Th2 differentiation by skin-resident dendritic cellsR01AI132576 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YOSUKE KUMAMOTO · 2017 to 2026
$3.8M
Mechanism of cDC2 subset differentiation in peripheral organsR01AI165622 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI YOSUKE KUMAMOTO · 2023 to 2026
$2.9M
Regulation of lung inflammation by crosstalk between dendritic cells and sensory neuronsR21AI180678 · NIAID · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI KUMAMOTO, YOSUKE · 2024 to 2025
$425k
National Institute of Allergy and Infectious Diseases R01AI132576National Institute of Allergy and Infectious Diseases R01AI165622National Institute of Allergy and Infectious Diseases R21AI180678NIAID NIH HHS R01 AI132576NIAID NIH HHS R01 AI165622NIAID NIH HHS R21 AI180678
6 · The paper itself

Abstract

Dendritic cells (DCs) play a crucial role in bridging innate and adaptive immunity by presenting antigens to prime antigen-specific T cells. Conventional DC (cDC) type 2 cells (cDC2s) are a phenotypically heterogeneous population of DCs highly capable of presenting antigens to CD4+ T cells. Studies found functional differences between different cDC2 subsets in regulating effector CD4+ T helper (Th) cells, but collaboration between different cDC subsets has also been suggested. In this review, we discuss recent advances in understanding the subset-specific role of cDC2s in regulating Th cells.

Indexed as

CD4-Positive T-LymphocytesDendritic CellsT-Lymphocyte SubsetsAnimalsAntigen PresentationCell CommunicationCell DifferentiationHumansLymphocyte Activationcell differentiationcell lineages and subsetsdendritic cellsprocessesTh1/Th2/Th17 cells

Identifiers

PMID41201234
PMCPMC12593281

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.