Observational studyJournal of cosmetic dermatology2025
Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross-Sectional Observational Study.
Observational study in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Hair Repigmentation Outcomes in Patients With Graying Hair Treated With Exosome Therapy: A Cross-Sectional Observational Study.Journal of cosmetic dermatology · 2025Observational
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHair graying is an age-associated condition primarily caused by the depletion and dysfunction of melanocyte stem cells within hair follicles. Emerging regenerative strategies, including exosome-based therapies, offer the potential to restore pigmentation by targeting underlying cellular mechanisms.
objectiveTo investigate the clinical outcomes and correlates of hair repigmentation following exosome-based therapy in individuals with gray hair.
methodsThis cross-sectional observational study enrolled 10 patients with visible gray or white hair who were treated with rose stem cell-derived exosomes (RSCEs) using various procedures. Gray hair repigmentation outcomes were assessed using a standardized scale. Statistical correlations between clinical variables and treatment responses were analyzed.
resultsA mean of 4.6 ± 1.3 treatment sessions was performed. Repigmentation was observed after an average of 2.4 ± 0.7 sessions and was maintained for 4.7 ± 1.9 months. The various treatment modalities also demonstrated efficacy in both hair regrowth and hair repigmentation. The mean outcome score was 2.8 ± 0.78, with 60% achieving a higher-grade response (≥ 50% improvement). Shorter duration of graying (p = 0.0363), presence of androgenetic alopecia (AGA) (p = 0.0332), and moderate baseline severity (Stage 2) (p = 0.0133) were significantly associated with better outcomes. No adverse events were reported.
conclusionExosome-based therapy appears to be a safe and promising approach for inducing hair repigmentation in individuals with gray hair using various treatment modalities. Factors such as the presence of AGA, shorter duration of graying, and moderate baseline severity may predict a better response. Larger, controlled studies are warranted to validate these findings and help standardize treatment protocols.
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