Evidence map›Paper›PMID 41201099›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Replacing BPA: Structural Substitutes BPAF Binding to the Progesterone Receptor Elevates Breast Cancer Risk.

Xiaotong Ji, Peilin Li, Haoyang Wu, Linzhuo Shen, Xiaoyun Wu, Peiyun Jiang, Yating Li, Xiaozheng Zhang, Huifeng Yue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xiaotong JiDepartment of Environmental Health, School of Public Health, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China.ORCID https://orcid.org/0000-0002-9949-8886
Peilin LiDepartment of Environmental Health, School of Public Health, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China.
Haoyang WuDepartment of Environmental Health, School of Public Health, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China.
Linzhuo ShenDepartment of Environmental Health, School of Public Health, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China.
Xiaoyun WuCollege of Environment and Resource, Research Center of Environment and Health, Shanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Shanxi University, Taiyuan, Shanxi, 030006, P. R. China.
Peiyun JiangDepartment of Environmental Health, School of Public Health, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China.
Yating LiDepartment of Environmental Health, School of Public Health, Shanxi Key Laboratory of Environmental Health Impairment and Prevention, MOE Key Laboratory of Coal Environmental Pathogenicity and Prevention, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China.
Xiaozheng ZhangDepartment of Biochemistry and Molecular Biology, Shanxi Key Laboratory of Birth Defect and Cell Regeneration, Shanxi Medical University, Taiyuan, Shanxi, 030001, P. R. China.
Huifeng YueCollege of Environment and Resource, Research Center of Environment and Health, Shanxi Key Laboratory of Coal-based Emerging Pollutant Identification and Risk Control, Shanxi University, Taiyuan, Shanxi, 030006, P. R. China.ORCID https://orcid.org/0000-0002-9862-0448

Funding

National Natural Science Foundation of China 22106098National Natural Science Foundation of China 22476120National Natural Science Foundation of China 22522607National Natural Science Foundation of China U23A20103Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi 2020L0174Shanxi Province Higher Education "Billion Project" Science and Technology Guidance ProjectStartup Foundation for Doctors of Shanxi Medical University XD1917Startup Foundation for Doctors of Shanxi Province SD1917Youth Science and Technology Research Foundation of Shanxi Province 20210302124298
6 · The paper itself

Abstract

As the global production of bisphenol analogs (BPs) surges to replace regulated bisphenol A (BPA), their pervasive environmental presence and uncharacterized breast cancer risk raise critical public health concerns. Herein, the environmental risks of BPs are deciphered by linking their structural affinity for the progesterone receptor (PR), a master regulator of breast cancer, to oncogenic outcomes across experimental tiers. Molecular simulations reveal that environmental BPAF and BPB exhibited stronger binding to the PR-ligand binding domain (LBD) than BPA. Chemical assays confirm persistent PR-LBD structural changes after BPs exposure, mimicking endocrine disruption patterns. The cellular thermal shift assay also confirms the interaction between the PR and BPs. In vitro, BPAF and BPF boost PR expression at human-relevant concentrations. In addition, BPAF elevates PR expression, and the enhanced migratory and invasive capacities are effectively suppressed by the PR inhibitor. Toxicological Prioritization Index-based risk stratification, weighted by the binding affinity of BPs to the PR and cellular toxicity, ranks BPAF as the highest-risk analog. Alarmingly, low-dose BPAF exposure (30 µg kg

Indexed as

Benzhydryl CompoundsBreast NeoplasmsPhenolsReceptors, ProgesteroneAnimalsBisphenol A CompoundsCell Line, TumorEndocrine DisruptorsFemaleFluorocarbonsHumansMiceProtein BindingBenzhydryl Compoundsbisphenol ABisphenol A Compoundsbisphenol AFEndocrine DisruptorsFluorocarbonsPhenolsReceptors, Progesteronebinding interactionbisphenol analogsbreast cancer riskprogesterone receptor

Identifiers

PMID41201099
PMCPMC12822391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.