Evidence map›Paper›PMID 41201096›Full record

ArticleACS infectious diseases2025

Identification and Characterization of a Small-Molecule Inhibitor of the

Filippo Vascon, Benedetta Fongaro, Vytautas Mickevičius, Antonella Pasquato, Birute Grybaite, Vidmantas Petraitis, Rahma Ben Abderrazek, Patrizia Polverino de Laureto, Donatella Tondi, Povilas Kavaliauskas and 1 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Filippo VasconDepartment of Biology, University of Padova, Via Ugo Bassi 58/b, Padova 35131, Italy.
Benedetta FongaroDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, Padova 35131, Italy.ORCID 0000-0003-0275-0190
Vytautas MickevičiusDepartment of Organic Chemistry, Kaunas University of Technology, Radvilenu Rd. 19, Kaunas LT-50254, Lithuania.
Antonella PasquatoDepartment of Surgery, Oncology and Gastroenterology, University of Padova, Via Giustiniani 2, Padova 35128, Italy.
Birute GrybaiteDepartment of Organic Chemistry, Kaunas University of Technology, Radvilenu Rd. 19, Kaunas LT-50254, Lithuania.
Vidmantas PetraitisCenter for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey 07110, United States of America.
Rahma Ben AbderrazekLaboratoire des Biomolécules, Venins et Applications Théranostiques, Institut Pasteur Tunis, Université Tunis El Manar, 13 Place Pasteur, Tunis 2092, Tunisia.
Patrizia Polverino de LauretoDepartment of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, Padova 35131, Italy.ORCID 0000-0002-0367-6781
Donatella TondiDepartment of Life Sciences, University of Modena and Reggio Emilia, Via Campi 103, Modena 41125, Italy.
Povilas KavaliauskasDepartment of Organic Chemistry, Kaunas University of Technology, Radvilenu Rd. 19, Kaunas LT-50254, Lithuania.
Laura CendronDepartment of Biology, University of Padova, Via Ugo Bassi 58/b, Padova 35131, Italy.ORCID 0000-0002-0125-0461

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SOS response is among the most conserved pathways that promote antibiotic resistance onset in bacteria. This study aimed to identify and characterize small-molecule inhibitors of the SOS response in the opportunistic pathogen

Indexed as

Anti-Bacterial AgentsPseudomonas aeruginosaSmall Molecule LibrariesSOS Response, GeneticsBacterial ProteinsHumansLexA Repressor ProteinMicrobial Sensitivity TestsRec A RecombinasesSerine EndopeptidasesAnti-Bacterial AgentsBacterial ProteinsLexA Repressor ProteinRec A RecombinasesSerine EndopeptidasesSmall Molecule Librariesantimicrobial resistanceLexAPseudomonas aeruginosaRecASOS responsevirulence

Identifiers

PMID41201096
PMCPMC12706794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.