Evidence map›Paper›PMID 41201043›Full record

ArticleOncology reports2026

Characterization of the anticancer effect of mebendazole and its interaction with standard cytotoxic drugs in patient tumor cells

Sharmineh Mansoori, Kristin Blom, Claes Andersson, Mårten Fryknäs, Rolf Larsson, Peter Nygren

Abstract read
In one paragraph

Article in Oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sharmineh MansooriDepartment of Medical Sciences, Akademiska Hospital (Uppsala University Hospital), 751 85 Uppsala, Sweden.
Kristin BlomDepartment of Medical Sciences, Akademiska Hospital (Uppsala University Hospital), 751 85 Uppsala, Sweden.
Claes AnderssonDepartment of Medical Sciences, Akademiska Hospital (Uppsala University Hospital), 751 85 Uppsala, Sweden.
Mårten FryknäsDepartment of Medical Sciences, Akademiska Hospital (Uppsala University Hospital), 751 85 Uppsala, Sweden.
Rolf LarssonDepartment of Medical Sciences, Akademiska Hospital (Uppsala University Hospital), 751 85 Uppsala, Sweden.
Peter NygrenDepartment of Immunology, Genetics and Pathology, Uppsala University, 751 85 Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mebendazole (Mbz), a well‑known anthelminthic drug, has demonstrated anticancer properties in tumor models and patients, and is thus under consideration for repositioning into an anticancer drug. Mbz is directly cytotoxic in cell lines by various mechanisms and acts indirectly via immunomodulation. In the present study, the anticancer effects of Mbz, alone and in combination with cytotoxic drugs, were further characterized using primary cultures of patient tumor cells

Indexed as

Antineoplastic AgentsAntineoplastic Combined Chemotherapy ProtocolsMebendazoleAnimalsCell Line, TumorCell ProliferationCisplatinDeoxycytidineFemaleGemcitabineHumansIrinotecanMiceMice, Inbred BALB CXenograft Model Antitumor AssaysAntineoplastic AgentsCisplatinDeoxycytidineGemcitabineIrinotecanMebendazolecancerdrug repositioningex vivoin vivomebendazole

Identifiers

PMID41201043
PMCPMC12612656

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.