Evidence map›Paper›PMID 41201016›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Steap4 Promotes Senile Osteoporosis via Fe

Liangliang Wang, Guangrong Yin, Wenming Li, Maoyuan Li, Feng Lu, Chao Xu, Gongyin Zhao, Dechun Geng, Jiaxiang Bai, Yuji Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Steap4 Promotes Senile Osteoporosis via FeAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Liangliang WangDepartment of Orthopaedics, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.ORCID https://orcid.org/0009-0001-4137-1532
Guangrong YinDepartment of Orthopaedics, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.
Wenming LiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.
Maoyuan LiDepartment of Orthopaedics, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.
Feng LuDepartment of Orthopaedics, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.
Chao XuDepartment of Orthopaedics, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.
Gongyin ZhaoDepartment of Orthopaedics, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.
Dechun GengDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University, Suzhou, 215006, China.ORCID https://orcid.org/0000-0003-4375-2803
Jiaxiang BaiDepartment of Orthopedics, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, China.
Yuji WangDepartment of Orthopaedics, the Second People's Hospital of Changzhou, the Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, China.ORCID https://orcid.org/0009-0006-0696-5630

Funding

Changzhou Sci&Tech Program CJ20230069China National Postdoctoral Program for Innovative Talents BX20230350China Postdoctoral Science Foundation 2024M753130Excellent Training Project of Changzhou Medical Center of Nanjing Medical University CMC2024PY03Jiangsu Medical Research Project ZD2022014Major Research Project of Changzhou Commission of Health ZD202217National Natural Science Foundation of China 82002321National Natural Science Foundation of China 82072425National Natural Science Foundation of China 82272567National Natural Science Foundation of China 82402780Natural Science Foundation of Jiangsu Province BK2021650Program of Suzhou Health Commission GSWS2022002Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM 2023IHM02007Scientific Research Project of Anhui Provincial Health Commission AHWJ2024Aa20475the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)the Special Project of Diagnosis and Treatment Technology for Key Clinical Diseases in Suzhou LCZX202003Top Talent of Changzhou "The14th Five-Year Plan" High-Level Health Talents Training Project 2022CZBJ060
6 · The paper itself

Abstract

Senile osteoporosis (SOP) is a systemic bone disease characterized by increased susceptibility to fractures. In this study, it is found that senescent bone marrow mesenchymal stem cells (BMSCs) exhibit increased sensitivity to ferroptosis, a phenomenon associated with Steap4, a nicotinamide adenine dinucleotide phosphate hydrogen (NADPH)-dependent metalloreductase that reduces Fe

Indexed as

AdipogenesisCCAAT-Enhancer-Binding Protein-betaFerroptosisMesenchymal Stem CellsOsteoporosisReactive Oxygen SpeciesAnimalsCellular SenescenceHumansIronMaleMiceMice, Inbred C57BLCCAAT-Enhancer-Binding Protein-betaIronReactive Oxygen SpeciesBMSCsferroptosisosteoporosissenescenceSteap4

Identifiers

PMID41201016
PMCPMC12850026

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.