Evidence map›Paper›PMID 41201015›Full record

ArticleMolecular medicine reports2026

Schisantherin A induces ferroptosis in non‑small cell lung cancer through activation of the YAP/ACSL4/TfR signaling pathway.

Wenxiang Zhu, Yeyang Chen, Xiangjian Wu, Xiaoyan Fu, Yongshi He, Yuxia Mo, Qinghua Zhu, Mingwen Tang, Zhiguang Zhai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenxiang Zhu *The Fourth Clinical Medical College, Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Yeyang Chen *School of Chinese Medicine, Studies and Applications of Internal Chinese Medicines, Hong Kong Baptist University, Hong Kong, SAR, P.R. China.
Xiangjian Wu *The Fourth Clinical Medical College, Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Xiaoyan FuThe Fourth Clinical Medical College, Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Yongshi HeThe Fourth Clinical Medical College, Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Yuxia MoThe Fourth Clinical Medical College, Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Qinghua ZhuThe Fourth Clinical Medical College, Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Mingwen TangThe Fourth Clinical Medical College, Department of Respiratory and Critical Care Medicine, Shenzhen Hospital of Traditional Chinese Medicine, Guangzhou University of Chinese Medicine, Shenzhen, Guangdong 518033, P.R. China.
Zhiguang ZhaiInstitute of Basic Theory for Chinese Medicine, Basic Research Center for Prevention and Treatment of Viral Diseases with Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Schisantherin A (Sch A), a compound derived from

Indexed as

Adaptor Proteins, Signal TransducingCarcinoma, Non-Small-Cell LungCoenzyme A LigasesCyclooctanesFerroptosisLignansLung NeoplasmsPolycyclic CompoundsReceptors, TransferrinSignal TransductionTranscription FactorsA549 CellsAnimalsCell Line, TumorCell SurvivalGene Expression Regulation, NeoplasticAdaptor Proteins, Signal TransducingCoenzyme A LigasesCyclooctanesLignansPolycyclic CompoundsReceptors, TransferrinTranscription FactorsYAP1 protein, humanYAP-Signaling Proteinsferroptosisnon‑small cell lung cancerschisantherin Ayes‑associated protein/acyl‑CoA synthase long‑chain family member 4/transferrin receptor

Identifiers

PMID41201015
PMCPMC12606556

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.