ReviewInternational journal of molecular medicine2026
Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review).
Review in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Lactate-Mediated Brain Acidosis Drives Epigenetic Dysregulation of TGFB2 and Associated Gene Networks in Schizophrenia and Bipolar Disorder.International journal of molecular sciences · 2026Article
- Risk analysis of the association between lactate-to-hematocrit ratio and poor prognosis in critical patients with cirrhosis.Medicine · 2026Article
- Lactylation-based machine algorithm combined with multi-omics analysis to predict prognosis in cervical cancer.Oncology letters · 2026Article
- Histone lactylation-mediated glycolysis-ferroptosis axis in neurological diseases.Frontiers in molecular neuroscience · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone lactylation, a novel epigenetic modification, has emerged as a critical mediator of various physiological and pathological processes. The present review elucidates the molecular mechanisms of lysine lactylation (Kla) and its influence on gene expression modulation. In addition, previous findings regarding the mechanisms of Kla and its impact on metabolic regulation, inflammation and tumorigenesis are summarized. Histone lactylation influences macrophage polarization, promotes tumor immune evasion, and affects osteoblast differentiation and embryonic development. While promising as a therapeutic target, research progress is currently hindered by methodological limitations in terms of lactylation quantification and manipulation. The current review not only summarizes fundamental insights into Kla‑mediated disease pathogenesis but also critically addresses existing knowledge gaps. By highlighting the dynamic interplay between lactylation and metabolic regulation, novel perspectives are provided on the biological importance of this posttranslational modification. Ultimately, the aim of this review is to identify innovative approaches for targeting lactylation‑mediated pathways in disease treatment.
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Registered trials
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