Evidence map›Paper›PMID 41201002›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation.

Zhishan Xu, Chao Lei, Mukesh K Sriwastva, Ting Wang, Amanguli Tuohongerbieke, Xiaotong Song, Collin Noud, Shannon Derkson, Yi Tan, Gerald Dryden and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhishan XuDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Chao LeiDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Mukesh K SriwastvaDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Ting WangDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Amanguli TuohongerbiekeDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Xiaotong SongDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Collin NoudDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Shannon DerksonDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.
Yi TanPediatric Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, 40202, USA.
Gerald DrydenDepartment of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Craig J McClainDepartment of Medicine, University of Louisville, Louisville, KY, 40202, USA.
Zhongbin DengDepartment of Surgery, Division of Immunotherapy, University of Louisville, Louisville, KY, 40202, USA.ORCID https://orcid.org/0000-0003-1409-5824

Funding

Role of oxidized linoleic acid metabolites in the pathogenesis of alcoholic liver diseaseP20GM113226 · NIGMS · UNIVERSITY OF LOUISVILLE · PI MCCLAIN, CRAIG J. · 2016 to 2025
$24.1M
Fibroblast Growth Factor 1 Prevents Hyperlipidemia and atherosclerosisR01HL160927 · NHLBI · UNIVERSITY OF LOUISVILLE · PI Yi Tan · 2022 to 2026
$2.7M
CSN8 regulation of S1P-enriched extracellular vesicles to modulate NAFLD by gut-liver axisR01DK115406 · NIDDK · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2018 to 2022
$2.0M
The role of neutral ceramidase in intestinal fucosylation and liver steatosis and inflammationR01DK131442 · NIDDK · UNIVERSITY OF LOUISVILLE · PI Zhong-Bin Deng · 2022 to 2026
$1.6M
Defining the role of S1p and myeloid cells during enterotoxigenic B. fragilis infectionR21AI159194 · NIAID · UNIVERSITY OF LOUISVILLE · PI DENG, ZHONG-BIN · 2021 to 2022
$430k
National Institutes of Health NIH P20GM113226National Institutes of Health NIH R01DK115406National Institutes of Health NIH R01DK131442National Institutes of Health NIH R01HL160927National Institutes of Health NIH R21AI159194NHLBI NIH HHS R01 HL160927NIAID NIH HHS R21 AI159194NIDDK NIH HHS R01 DK115406NIDDK NIH HHS R01 DK131442NIGMS NIH HHS P20 GM113226NIGMS NIH HHS P20GM113226
6 · The paper itself

Abstract

Sphingolipids play a crucial role in gut inflammation. Neutral ceramidase (NcDase) serves as a pivotal regulator of ceramide, the central intermediate in sphingolipid metabolism. The contribution of intestinal epithelial cells (IEC) NcDase to colitis is not well understood. Here, a protective mechanism by which IEC NcDase deficiency (Asah2

Indexed as

ColitisGangliosidesInflammationNeutral CeramidaseT-Lymphocytes, RegulatoryAnimalsDisease Models, AnimalIntestinal MucosaMacrophagesMiceMice, Inbred C57BLSialyltransferasesganglioside, GD3GangliosidesNeutral CeramidaseSialyltransferasescolitisgangliosidesmacrophagesSiglecsST8SIA1

Identifiers

PMID41201002
PMCPMC12849859

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.