ArticleSe pu = Chinese journal of chromatography2025
[Determination of 29 organic acids in tobacco based on isopropyl esterification derivatization by gas chromatography-mass spectrometry].
Article in Se pu = Chinese journal of chromatography, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Key aroma and smoke components influencing sensory quality of heated tobacco products.Frontiers in plant science · 2026Article
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5 authors.
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Abstract
Organic acids are important components of dry tobacco and significantly affect its sensory properties. Therefore， determining the organic-acid composition and content in tobacco is greatly significant for evaluating its quality. Organic acids in tobacco are classified according to volatility as either volatile， semi-volatile， or non-volatile， with semi-volatile and non-volatile organic acids typically methylated for identification purposes. However， volatile acids cannot be determined in this manner owing to their low molecular weights. Therefore， a comprehensive， efficient， and accurate method for rapidly and simultaneously determining volatile， semi-volatile， and non-volatile organic acids in tobacco needs to be established. Herein， an innovative gas-chromatography-mass-spectrometry-based （GC-MS-based） isopropyl-esterification method was developed for simultaneously determining 29 volatile， semi-volatile， and non-volatile organic acids in tobacco. The developed method provides esterified small-molecule acids of lower volatility than those obtained using classical methylation and avoids interference from byproducts obtained via the esterification reaction. Experimental conditions and GC parameters were optimized， which ultimately led to 10% sulfuric acid in isopropanol （containing 0.1 g/mL
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