Evidence map›Paper›PMID 41200954›Full record

ArticlePlatelets2025

Use of a conditional Glanzmann thrombasthenia mouse model reveals a supportive and possibly non-adhesive role for TLT-1 in the platelet-fibrinogen interaction.

Siobhan Branfield, Nicholas Koshy, Yashieta Somani, Barbara Manfredi, Caitlin Schneider, Hanan Tlais, Vandre Figueiredo, Randal Westrick, A Valance Washington

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Platelets, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siobhan BranfieldDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Nicholas KoshyDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Yashieta SomaniDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Barbara ManfrediDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Caitlin SchneiderDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Hanan TlaisDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Vandre FigueiredoDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
Randal WestrickDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.
A Valance WashingtonDepartment of Biological Sciences, Oakland University, Rochester, MI, USA.ORCID 0000-0002-3458-1822

Funding

Translation Studies of the Planet Specific Receptor Trem Like Transcript (TLT)R01HL090933 · NHLBI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI WASHINGTON, A. VALANCE · 2011 to 2022
$2.9M
NHLBI NIH HHS R01 HL090933
6 · The paper itself

Abstract

The platelet integrin receptor, αIIbβ3, binds fibrinogen to mediate platelet-platelet contacts, regulate hemostasis, and modulate inflammation. The Triggering Receptor Expressed in Myeloid (TREM) - Like (TLT)-1 is an enigmatic 34kD receptor found on platelets that affects their hemostatic and inflammatory functions. Similar to αIIbβ3, TLT-1's ligand is also fibrinogen; however, TLT-1's direct role in platelet function remains unknown. We created a tamoxifen-inducible conditional αIIb deficient (

Indexed as

Blood PlateletsFibrinogenThrombastheniaAnimalsDisease Models, AnimalMiceMice, KnockoutFibrinogenFibrinogenhemostasis, thrombosisplateletsTLT-1αIIbβ3

Identifiers

PMID41200954
PMCPMC12805433

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.