ArticleCroatian medical journal2025
The role of miR-145, miR-200c, and miR-21 in distinguishing between hyperplastic and adenomatous colon polyps and colorectal cancer prediction.
Article in Croatian medical journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Evaluation of agmatine's anti-cancer efficacy in Caco-2 colorectal adenocarcinoma cells.Medical oncology (Northwood, London, England) · 2026Article
- The role of exosomal long non-coding RNAs in head, neck and thyroid cancers.Medical oncology (Northwood, London, England) · 2025Review
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Authors and funding
5 authors.
Funding
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Abstract
aimTo assess whether miRNA expression can be a biomarker for distinguishing between hyperplastic and adenomatous polyps and colon cancer tissues.
methodsThe study involved 40 colon adenocarcinoma (CA) tissue samples, 40 low-grade adenomatous (A) polyps, and 40 hyperplastic (HP) polyps. The samples were formalin-fixed and paraffin-embedded. Quantitative real-time polymerase chain reactions were used to determine the expression levels of miR-21, miR-200c, and miR-145.
resultsmiR-145 expression was significantly lower in the CA than in both the A and HP groups (P=0.012 and P=0.004, respectively) and in the A than in the HP group (P=0.028). miR-200c expression was higher in the CA than in the A (P=0.008) and HP groups (P=0.009), while no difference was observed between the A and HP groups (P=0.624). miR-21 showed a stepwise increase across the groups, with the highest levels in the CA, followed by the A and HP groups (P<0.001 for both CA vs A and CA vs HP; P=0.037 for A vs HP).
conclusionThe study revealed dysregulated expression of miR-145 and miR-21 in colon polyps and cancer tissue, showing that these miRNAs may be used to distinguish between hyperplastic and adenomatous polyps and predict colorectal cancer.
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Identifiers
41200944PMC12623251What OpenQuestion holds
Registered trials
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