ArticleAnnals of neurology2026
Association between Human Leukocyte Antigen Alleles and Neuropathological Outcomes in Lewy Body Disease.
Article in Annals of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveLewy body disease (LBD) is a complex neurodegenerative disorder characterized by the accumulation of misfolded α-synuclein in the brain. Neuroinflammation has long been implicated in LBD pathogenesis, and recent genetic studies in Parkinson's disease (a clinical manifestation of LBD) have shown consistent association with the human leukocyte antigen (HLA) gene complex. Here, we assessed whether variation in HLA alleles influences neuropathological burden in a neuropathologically-defined series of LBD cases.
methodsWe conducted a comprehensive analysis of HLA allelic variants in a cohort of 539 LBD cases of European descent from the Mayo Clinic brain bank. High-resolution whole-genome sequencing was used, and the HLA alleles of each sample were called using the HLA*LA tool and assessed for association with neuropathological outcomes.
resultsOur analysis identified 1 significant (P < 3.43 × 10
interpretationThis study provides a detailed evaluation of the relationship between HLA alleles and LBD pathology, highlighting the importance of immune-related genetic factors in the etiology of LBD. ANN NEUROL 2026;99:492-501.
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