Evidence map›Paper›PMID 41200654›Full record

ArticleCureus2025

Gallbladder Pneumatosis With Pneumoperitoneum Caused by Clostridium perfringens: A Case Report.

Bethany J Ashton, Subiksha Subramonian, Manoj Nair

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Bethany J AshtonGeneral Surgery, North Middlesex University Hospital, London, GBR.
Subiksha SubramonianGeneral Surgery, North Middlesex University Hospital, London, GBR.
Manoj NairGeneral Surgery, North Middlesex University Hospital, London, GBR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emphysematous cholecystitis (EC) is a rare, life-threatening variant of acute cholecystitis characterised by gas formation within the lumen and walls of the gallbladder. This reflective case report describes a rare presentation of EC complicated by pneumoperitoneum, without free bile or identifiable perforation. It highlights the diagnostic challenges and the management considerations associated with this severe condition. A 64-year-old male with type 2 diabetes mellitus, hypertension, obesity and other comorbidities presented with a six-day history of abdominal pain and bloating. Blood tests revealed marked leukocytosis with neutrophilia and an elevated C-reactive protein. Despite an unremarkable abdominal exam, CT imaging revealed gas within the gallbladder lumen, walls and free intraperitoneal air, without associated free fluid or bile. Emergency laparoscopic cholecystectomy revealed a necrotic, gas-containing gallbladder and localised pus, but no perforation. The patient recovered well with targeted antibiotic therapy. This case highlights that pneumoperitoneum in the absence of free bile or visible perforation can occur in EC. Awareness of this atypical presentation is critical to avoid diagnostic delay and ensure timely surgical management.

Indexed as

cholecystitisclostridium perfringensemphysematous cholecystitislaparoscopic cholecystectomypneumoperitoneum

Identifiers

PMID41200654
PMCPMC12588263

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.