ArticleCureus2025
Investigating the Dosimetric Impact of Acuros XB in Lung Cases Before Clinical Implementation.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background This study aims to present a simple and reliable way to study the dosimetric impact of the Acuros XB (AXB) algorithm compared to the Anisotropic Analytical Algorithm (AAA). Volumetric modulated arc therapy (VMAT) plans for lung cancer treatments were studied when changing the planning target volume (PTV) margins, positions, and interface distances. Methodology Three PTV positions were studied: near an air/tissue interface (PTVint), at the upper lobe surrounded by air (PTVair), and at the mediastinum (PTVtis). For the PTV near the interface, four VMAT plans were created, expanding the PTV margin and reducing the air/tissue interface distance at the same time. The margins were set to 0.5 cm, 0.7 cm, 1 cm, and 1.5 cm from the gross target volume (GTV). Differences in dose distributions between AXB and AAA occurred in all PTVs, with the maximum differences seen in PTVs including more air volume. Results For PTVtis, the two algorithms presented similar behavior. Specifically, for PTV mean dose (D
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