ArticleCureus2025
Paraneoplastic Central and Peripheral Demyelination Secondary to Oesophagus Malignancy: A Case Report.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A man in his 60s presented with subacute weakness of his lower limbs, numbness, and urinary retention, preceded by fever a few weeks back. Nerve conduction studies showed demyelinating parameters, and magnetic resonance imaging showed long-segment cord T2/STIR hyperintensities and multifocal lesions in the brain. CSF showed albuminocytologic dissociation. Despite immunotherapy with intravenous immunoglobulin (IVIg), symptoms progressed. A PET-CT scan revealed thoracic oesophageal malignancy with lymphatic spread, confirmed on biopsy as an undifferentiated carcinoma. The case was diagnosed as paraneoplastic demyelination involving both the central and peripheral nervous systems. The patient later developed pulmonary thromboembolism. This case highlights simultaneous central and peripheral demyelination as a paraneoplastic manifestation and underscores the need for malignancy screening in demyelinating syndromes unresponsive to standard immunotherapies.
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