Evidence map›Paper›PMID 41200535›Full record

ReviewNeurosurgery practice2025

Efficacy and Safety of Radiosurgery in Cavernous Sinus Meningioma: A Systematic Review and Single Meta-Analysis.

Lucca B Palavani, Raphael Camerotte, Marina Vilardo, Bernardo Vieira Nogueira, Lucas Pari Mitre, Paulo Victor Zattar Ribeiro, Henrique Lepine, Leonardo B O Brenner, Filipi Fim Andreão, Fábio Torregrossa and 5 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurosurgery practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lucca B PalavaniDepartment of Neurosurgery, Max Planck University Center, Indaiatuba, São Paulo, Brazil.
Raphael CamerotteDepartment of Neurosurgery, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Marina VilardoDepartment of Neurosurgery, Catholic University of Brasília, Brasília, Brazil.
Bernardo Vieira NogueiraDepartment of Neurosurgery, Serra dos Órgãos University Center, Teresópolis, Rio de Janeiro, Brazil.
Lucas Pari MitreFaculty of Medicine, Santa Casa de São Paulo School of Medical Sciences, São Paulo, Brazil.
Paulo Victor Zattar RibeiroDepartment of Medical Genetics, State University of São Paulo, Ribeirão Preto, São Paulo, Brazil.
Henrique LepineDepartment of Neurosurgery, University of São Paulo School of Medicine (FMUSP), São Paulo, Brazil.
Leonardo B O BrennerDepartment of Neurosurgery, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil.
Filipi Fim AndreãoDepartment of Neurosurgery, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Fábio TorregrossaDepartment of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Thiago Scharth MontenegroDepartment of Neurosurgery, Spectrum Health/Michigan State University, Grand Rapids, Michigan, USA.
Raphael BertaniDepartment of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Fábio Ynoe MoraesDepartment of Oncology, Queen's University, Kingston, Canada.
Marcos Vinicius Calfat MaldaunDepartment of Neurosurgery, Sírio Libanês Hospital, São Paulo, Brazil.
Cleiton FormentinDepartment of Neurosurgery, Sírio Libanês Hospital, São Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesMeningiomas are the most common primary central nervous system tumors, with cavernous sinus meningiomas (CSMs) making up a small fraction (1% of intracranial tumors). CSMs are challenging to treat due to their location and potential invasion. Therapy methods have shifted from aggressive resections to less invasive techniques such as stereotactic radiosurgery, reducing morbidity and improving survival. This study reviews the effectiveness and safety of radiosurgery for CSMs, blending historical and contemporary approaches to guide future treatments.

methodsA search was performed in MEDlINE, Embase, and Cochrane databases, following Cochrane and Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Eligible studies included randomized or observational studies with ≥4 patients reporting on radiosurgery for CSM. The random-effects model was used to calculate a single proportion analysis with 95% CIs. Statistical analyses were performed using RStudio.

resultsTwenty seven studies, encompassing 1851 patients, were included in this analysis, with a population median age of 27 years. Outcomes were assessed as follows: the 10-year progression-free survival rate was 87% (323 patients; 95% CI: 73%-100%; I

conclusionThis study reveals stereotactic radiosurgery as an effective treatment of CSMs, showing high long-term progression-free survival and significant tumor control with few complications.

Indexed as

Cavernous sinusMeningiomasStereotactic radiosurgery (SRS)Treatment effectiveness

Identifiers

PMID41200535
PMCPMC12588698

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.