ArticleClinical case reports2025
Generalized Bullous Fixed Drug Eruption Secondary to Levocetirizine: A Lesson Learned!
Article in Clinical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Levocetirizine-induced paradoxical fixed drug eruption: A case report with causality assessment.Indian journal of pharmacology · 2026Article
- Generalized Bullous Fixed Drug Eruption Secondary to Levocetirizine: A Lesson Learned!Clinical case reports · 2025Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fixed drug eruption (FDE) is a unique type of adverse drug eruption characterized by a well-defined erythematous to violaceous patch that recurs at the same site upon re-exposure to causative drugs and resolves with hyperpigmentation. This distinct drug reaction is a type IV hypersensitivity reaction that is mediated by memory CD8+ T cells that reside in the basal layer of the epidermis of resting FDE lesions. Generalized bullous FDE (GBFDE) is the most severe form of FDE, presenting with widespread blisters and erosions that can be misdiagnosed as epidermal necrolysis. There are only two reports of levocetirizine-induced GBFDE in the literature to date. We hereby present a case of a 65-year-old male with GBFDE due to levocetirizine, which was misattributed to a more commonly implicated drug, that is, acetaminophen.
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Registered trials
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