ArticleFrontiers in neurology2025
Systemic immune-inflammation index associated with functional outcomes after endovascular thrombectomy in anterior circulation acute ischemic stroke.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Systemic immune-inflammation index predicts hemorrhagic transformation after endovascular therapy for ischemic stroke.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Admission Inflammatory-Metabolic Biomarker Profiles and Outcome-Specific Prognostic Patterns After Endovascular Therapy for Acute Ischemic Stroke: A Multicenter Cohort Study.Journal of inflammation research · 2026Article
- Admission systemic inflammatory indices and 6-month functional outcome after endovascular thrombectomy for acute ischemic stroke: an exploratory single-center cohort study.Frontiers in neurology · 2026Article
- Systemic immune-inflammation index predicts post-thrombectomy outcomes and reveals a mediating role in the association between neurocardiac stress and prognosis: a multicenter study.Frontiers in neurologyArticle
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Authors and funding
5 authors.
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Abstract
Background: Many patients undergoing endovascular thrombectomy (EVT) for anterior circulation acute ischemic stroke experience poor outcomes despite successful recanalization. The systemic immune-inflammation index (SII) integrates multiple inflammatory pathways. We aimed to evaluate the association between SII and clinical outcomes in anterior circulation stroke patients undergoing EVT. Methods: This retrospective study included 741 consecutive patients who underwent EVT for anterior circulation stroke at a tertiary center between January 2021 and December 2024. SII was calculated as platelet count × neutrophil count/lymphocyte count within 24 h. The primary outcome was poor functional outcome (modified Rankin Scale 3-6) at 3 months. The safety endpoint was symptomatic intracranial hemorrhage (sICH). Associations were examined using multivariable logistic regression and cubic spline analyses. Results: The median SII was 1,247.9 [IQR: 804.9-2127.1]. Poor functional outcome occurred in 317 (42.8%) patients. After adjustment, log-transformed SII was independently associated with poor functional outcome (OR 1.428, 95% CI 1.159-1.759, Conclusions: In anterior circulation stroke patients undergoing EVT, elevated SII is independently associated with poor functional outcome but not symptomatic hemorrhagic complications.
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