Evidence map›Paper›PMID 41200337›Full record

ArticleOpen veterinary journal2025

Teratogenic effects of thiamethoxam on female rats and possible protective function of ascorbic acid.

Ibrahim A Hamed, Refat M Sherif, Aly A Shalaby, Omran E Abdoslam, Qiyi He, Dongyang Li, Ting Xu, El-Sayed A El-Sheikh

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Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ibrahim A HamedPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Refat M SherifPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Aly A ShalabyPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.
Omran E AbdoslamDepartment of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, University of Tripoli, Tripoli, Libya.
Qiyi HeCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.
Dongyang LiCollege of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, China.
Ting XuBeijing Key Laboratory of Biodiversity and Organic Farming, College of Resources and Environmental Sciences, China Agricultural University, Beijing, China.
El-Sayed A El-SheikhPlant Protection Department, Faculty of Agriculture, Zagazig University, Zagazig, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Continuous exposure of pregnant females to thiamethoxam (THM) during the organogenesis period causes reproductive toxicity through oxidative stress mechanisms, changes in fetal size and weight, (visceral and skeletal) malformations, histological changes in tissues, and oxidative stress in dams. Aim: This study aimed to investigate the toxicological effects of 1/10 and 1/20 of THM LD Methods: Forty-eight female rats were divided into six equal groups and were orally treated daily with THM, vit C, and their combinations during the organogenesis period [6th-12th gestation day (GD)]. All pregnant female rats were slaughtered on GD 20. Blood samples, tissues (brain, liver, kidney, and lung), fetuses, and the uterus were examined. Results: Females orally treated with 1/10 and 1/20 of THM LD Conclusion: The results showed the potential of vit C in decreasing teratogenic effects on dams and fetuses exposed to THM, as it reduced the negative effects on different organs of the treated rats.

Indexed as

AntioxidantsAscorbic AcidInsecticidesNeonicotinoidsNitro CompoundsTeratogensThiamethoxamAnimalsFemaleFetusOxidative StressPregnancyRatsRats, WistarAntioxidantsAscorbic AcidInsecticidesNeonicotinoidsNitro CompoundsTeratogensThiamethoxamMalondialdehydePregnant ratsThiamethoxamTotal antioxidantVitamin C

Identifiers

PMID41200337
PMCPMC12587883

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.