ArticleOpen veterinary journal2025
Protective role of coenzyme Q10 against renal and hepatic toxicity induced by acetaminophen overdose in albino rats.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Varied Effects of Carnosine and an Antioxidant-Enriched Carnosine Supplement in Paracetamol-Induced Hepatotoxicity Model in Mice.Current issues in molecular biology · 2026Article
- Assessing the effects of linseed consumption on thyroid hormones and hepatic toxicity in rats drenched with Cordarone overdose.Open veterinary journal · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Acetaminophen has an antipyretic activity by inhibiting prostaglandin synthesis found in the brain, and this action is responsible for its analgesic effect, but overdose can cause hepatic and renal toxicity. Coenzyme Q10 has cytoprotective properties through antioxidant and anti-inflammatory effects. In addition, it plays a role in energy production in the mitochondria, making it important in reducing cellular damage by toxic agents. Aim: This study aimed to evaluate the potential protective effect of CoQ10 against acetaminophen toxicity on liver and kidney functions. Methods: Thirty adult male albino rats were randomly subdivided into three groups: control group, acetaminophen group, acetaminophen + CoQ10 group, acetaminophen in toxic dose (500 mg/kg) orally, and acetaminophen + CoQ10 group, drenched with coenzymeQ10 (10 mg/kg) orally, then acetaminophen in toxic dose (500 mg/kg). Dosing continued for 30 days. Blood was collected for biochemical analysis of hepatic and renal biochemical parameters. Results: Acetaminophen induced hepatic injury as measured by increased hepatic biochemical parameters "Total serum bilirubin (TSB), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT)" ( Conclusion: Coenzyme Q10 can reduce the toxicity of acetaminophen overdose by acting as an antioxidant agent that reduces tissue and organ damage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.