ArticleOpen veterinary journal2025
Molecular and pathological confirmation of natural feline coronavirus infection in a captive persian leopard (
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Feline coronavirus (FCoV) infection, which can lead to feline infectious peritonitis (FIP), poses significant risks to domestic and wild felids. Although FIP has been documented in various non-domestic species, no cases have been reported in the Persian leopard ( Case Description: A 3-year-old female Persian leopard exhibited lethargy, watery diarrhea, hematochezia, and anorexia. The initial treatment with gentamicin resolved the gastrointestinal symptoms, but the systemic signs persisted. Molecular diagnostics (Reverse Transcription Polymerase Chain Reaction targeting the FCoV M gene) and immunohistochemistry (IHC) confirmed the presence of FCoV Postmortem examination revealed pyogranulomatous inflammation, vasculitis, and effusive fluid accumulation, consistent with FIP. Treatment with GS-441524, polyprenyl immunostimulant, and glucocorticoids was unsuccessful. Conclusion: This case represents the first documented occurrence of FIP in a Persian leopard, highlighting the threat of FCoV to endangered felids. Enhanced surveillance and preventive measures in captive populations are urgently required.
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