ArticleOpen veterinary journal2025
Validation method for determining the concentration of norfloxacin-tylosin combination in broiler chicken tissue using high-performance liquid chromatography.
Article in Open veterinary journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Bibliometric analysis of pharmacokinetic research on the combination of norfloxacin and tylosin in poultry and reptiles.Open veterinary journal · 2026Article
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8 authors.
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Abstract
Background: The combination of norfloxacin and tylosin is an alternative to prevent antibiotic residue and resistance. Measurement of the levels of the combination of norfloxacin-tylosin in tissue using high-performance liquid chromatography (HPLC) to obtain parameters for further research, such as pharmacokinetics and residue analysis. When broiler chickens are given norfloxacin-tylosin antibiotics, they make antibiotics more effective against bacterial illnesses. These results indicate that the right mix of antibiotics can be used as a single medicine to achieve synergistic effects. Also, reach the SDGs for no hunger, good health, and well-being. Aim: This study aimed to ascertain the correct validation method for the combination antibiotic norfloxacin-tylosin in broiler chicken tissues, specifically the liver, kidney, and muscle. Methods: HPLC consistently detected norfloxacin-tylosin in broiler chicken tissue. Mobile phase methanol/acetonitrile was 50:50 (v/v). The chromatographic equipment utilized a 250 mm Shimpack ODS C18 column with a four μm diameter. Solution detection happened at a 1 ml/minutes flow rate, 30°C oven temperature, and 20 μl injection volume. Light had a wavelength of 279 nm. In Bogor, Indonesia, PT Mensana Aneka Satwa manufactured liquid antibiotics and combined them with broiler chicken tissue from 28-day-old antibiotic-free-fed chicks. Results: The tissue, liver, kidney, and muscle showed linearity values of Conclusion: According to the European Medicines Agency Guideline, the mixed solution of norfloxacin and tylosin demonstrated favourable outcomes regarding sensitivity, specificity, linearity, accuracy, and precision.
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