Top motor and non-motor complaints in patients with Parkinson's disease.

Background: Parkinson's disease (PD) is characterized by several motor and non-motor manifestations. These variable neurological complaints have diverse intensity and cause various degrees of disability. Objective methods: We aimed to assess the top three most troublesome neurological complaints in patients with PD and correlated them with demographic and clinical variables, including the cognitive status assessed by the Montreal Cognitive Assessment (MoCA). Patients were asked about their three most troublesome neurological complaints after reviewing all motor and non-motor symptoms. Responses were divided into three tiers. Results: We studied 230 consecutive patients with PD. There were 130 (56.5%) male patients, with the mean age at evaluation of 67.7 ± 11.06 years. The most common neurological complaints in the top tier were (1) tremor ( Conclusion: Overall, tremor was the most troublesome symptom in patients with PD, though high variability was observed. Approximately 69% of patients had at least one non-motor symptom among their top-3 complaints, which was associated with abnormal cognitive status. Speech difficulties, dyskinesia, and insomnia became more prominent with disease progression. Among patients with non-motor symptoms in the top three tiers, those with a PIGD phenotype or prominent dyskinesia exhibited a higher frequency of fatigue, insomnia, pain, and anxiety, suggesting a clustering effect of non-motor symptoms with these motor presentations.