Evidence map›Paper›PMID 41200273›Full record

ArticleFrontiers in aging neuroscience2025

Gender-related differences in cognitive performance and cognitive stimulation efficacy in subjects with Parkinson's disease and mild cognitive impairment.

Noemi Iaccino, Jolanda Buonocore, Giusi Torchia, Francesca Curcio, Fabio M Pirrotta, Marianna Contrada, Loris Pignolo, Antonio Gambardella, Gennarina Arabia

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In one paragraph

Article in Frontiers in aging neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Noemi IaccinoDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.
Jolanda BuonocoreDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.
Giusi TorchiaDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.
Francesca CurcioDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.
Fabio M PirrottaDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.
Marianna ContradaRegional Center for Serious Brain Injuries, S. Anna Institute, Crotone, Italy.
Loris PignoloRegional Center for Serious Brain Injuries, S. Anna Institute, Crotone, Italy.
Antonio GambardellaDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.
Gennarina ArabiaDepartment of Medical and Surgical Sciences, Institute of Neurology, Magna Graecia University, Catanzaro, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gender-related differences in cognitive performances of subjects with Parkinson's Disease and mild cognitive impairment (MCI-PD) have been recently investigated in a few studies, yielding heterogeneous results. Cognitive stimulation (CS) is a promising non-pharmacological treatment in MCI-PD subjects and no data regarding gender differences in its efficacy are available yet. The aim of this study was to investigate gender-related differences in cognitive functions and CS efficacy in subjects with MCI-PD. Methods: Forty-five MCI-PD subjects (30 men, 15 women) were randomized to a 4-week CS program, delivered either via tele-rehabilitation (TR) or with a conventional in-person approach. A broad clinical and neuropsychological assessment, including the Cognitive Reserve Index questionnaire, was conducted at baseline (T1), post-treatment (T2), and at 6-month follow-up (T3). Results: At baseline, women showed a lower cognitive reserve (CR) compared to men ( Conclusion: Our study showed gender-related differences both in cognitive functions and in efficacy of CS in subjects with MCI-PD, also highlighting the role of cognitive reserve. These findings support the relevance of developing gender-tailored cognitive rehabilitation strategies to enhance treatment outcomes and improve the quality of life for individuals with MCI-PD.

Indexed as

cognitive impairmentcognitive reservecognitive stimulationgenderneuroscienceParkinson’s disease

Identifiers

PMID41200273
PMCPMC12585997

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.