ReviewFrontiers in psychiatry2025
Exploring the complex mechanisms of post-intracerebral hemorrhage depression: towards personalized treatment approaches.
Review in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Early emotional interventions for post-stroke functional prognosis: a systematic review and meta-analysis.Frontiers in neurologyPooled it
- Serum prealbumin at admission is associated with post-stroke depression at 3 months in patients with spontaneous intracerebral hemorrhage.Frontiers in psychiatry · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post - stroke depression (PSD) is a common mental disorder after stroke that significantly impacts patients' quality of life. While research on depression after ischemic stroke has made progress, the mechanisms of depression after cerebral hemorrhage remain unclear. The incidence of depression after cerebral hemorrhage is high, ranging from 18% to 60%, which greatly affects patients' rehabilitation and quality of life. This article reviews the pathogenesis, clinical manifestations, and treatment approaches for depression following intracerebral hemorrhage (ICH), emphasizing its distinct characteristics and therapeutic challenges, while also outlining potential directions for future research. The development of depression after ICH is multifactorial and complex. Firstly, disruptions in neurotransmitter systems may be a critical underlying mechanism. Secondly, neuroinflammatory processes likely contribute to its onset. Additionally, the interplay between neural network reorganization and psychosocial factors must also be considered. Current treatments for depression after a brain bleed include medication, non-drug therapies, and teamwork among healthcare professionals. Medications can help balance brain chemicals to reduce symptoms. Non-drug therapies, like counseling and support groups, offer emotional help and ways to manage stress. Working together, doctors, therapists, and other experts create personalized plans to improve recovery. Future research should focus on combining precision medicine and new technologies to improve personalized treatment and practical use for depression after ICH. Precision medicine can customize care based on a patient's unique traits, such as genetic data and biological markers. Advances in brain imaging and genetic testing can help us better understand the causes of this condition and provide more effective and tailored treatments.
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Registered trials
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