SynthesisFrontiers in medicine2025
Incidence and factors associated with postoperative delirium after primary total joint arthroplasty in older adults: a systematic review and meta-analysis.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Motor-Sparing Regional Analgesia in Frail and Sarcopenic Older Adults Undergoing Total Knee Arthroplasty: From Anatomy to Clinical Decision-Making-A Narrative Review.Journal of clinical medicine · 2026Review
- Association between age and postoperative delirium after hip or knee replacement: a secondary analysis of a publicly available dataset.BMC anesthesiology · 2026Article
- Perioperative Outcomes of Cemented vs Cementless Total Hip Arthroplasty: A National Inpatient Sample Study of 81,668 Elective Procedures.Journal of clinical medicine · 2026Article
- Metabolic syndrome and perioperative neurocognitive disorders: epidemiology, mechanisms, and interventions.Frontiers in neuroscience · 2026Review
- Postoperative delirium risk in elderly high-risk patients undergoing hip and knee arthroplasty (ASA Ⅲ-Ⅳ): construction and validation of a nomogram model based on frail frailty index.Frontiers in medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The proportion of older adults undergoing total joint arthroplasty (TJA) is increasing annually. Postoperative delirium (POD) is a common and serious complication among older adults after surgery. However, the incidence and factors associated with POD following primary TJA in this population remain unclear. Objective: This study aimed to assess the incidence of delirium after primary TJA in older adults and to identify factors associated with POD through a meta-analytic approach. Methods: A systematic literature search was performed in PubMed, Embase, Web of Science, and the Cochrane Library for studies published from inception to June 2025. Observational studies reporting POD incidence following TJA, including total hip arthroplasty and total knee arthroplasty in older adults (aged ≥60 years), were included. Pooled incidence rates and factors associated with POD were estimated using a random-effects model. Results: After applying the inclusion and exclusion criteria, 35 studies involving 29,311 older adults undergoing TJA were included. The pooled POD incidence was 13.6% (95% CI, 12.2-15.0%), with substantial heterogeneity across studies. Advanced age, sleep apnea, hypertension, diabetes mellitus, coronary artery disease, stroke, chronic obstructive pulmonary disease, renal disease, solid tumors, dementia, Parkinson's disease, psychiatric disorders, ASA class III/IV, substance use history, and blood transfusion were associated with increased POD risk. Conversely, higher educational attainment was identified as a protective factor. Conclusion: This study systematically reported POD incidence among older adults undergoing TJA and identified factors associated with POD These findings provide evidence to optimize perioperative management and develop prevention strategies for POD in this population. Systematic review registration: This study was registered in INPLASY platform (number: INPLASY202570015).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.