ArticleAnnals of gastroenterological surgery2025
Association Between Cholecystectomy and Gastric Cancer in a Cohort Study in Taiwan.
Article in Annals of gastroenterological surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The association between cholecystectomy and gastric cancer is undetermined. The objective of this study was to assess whether subjects with cholecystectomy are at risk of gastric cancer in Taiwan. Methods: This study used data from a cohort of 2 000 000 beneficiaries over a twelve-year period (2010-2021) from the Taiwan National Health Insurance Research Database. A total of 24 798 subjects aged 20 to 84 years underwent cholecystectomy, constituting the cholecystectomy group. An additional 68 781 randomly selected subjects without a history of cholecystectomy were included as the noncholecystectomy group. The incidence of gastric cancer was measured in both groups through the end of 2021. A multivariable Cox proportional hazards regression model was used to assess the hazard ratio (HR) and 95% confidence interval (CI) for the risk of gastric cancer, adjusting for covariables. Results: The overall incidence rate of gastric cancer was 1.02 times higher in the cholecystectomy group than in the noncholecystectomy group; however, this difference was not statistically significant (5.70 vs. 5.60 per 10 000 person-years, 95% CI = 0.80-1.31, Conclusion: This cohort study does not detect a significant association between cholecystectomy and gastric cancer risk.
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