ArticleAnnals of gastroenterological surgery2025
Long-Term Survival of Two Versus Three Courses of Preoperative Cisplatin and Fluorouracil Plus Docetaxel for Locally Advanced Esophageal Cancer: A Multicenter Randomized Phase II Trial.
Article in Annals of gastroenterological surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Clinical Outcomes of First-Line Immune Checkpoint Inhibitor-Based Therapy for Postoperative Recurrence After Adjuvant Nivolumab in Esophageal Cancer.Annals of surgical oncology · 2026Article
- Treatment-dependent and independent prognostic value of inflammation-based nutritional indices in immune checkpoint inhibitor-based therapy for esophageal cancer.Esophagus : official journal of the Japan Esophageal Society · 2026Article
- Risk Stratification of Postoperative Recurrence After Adjuvant Nivolumab for Resected Locally Advanced Esophageal Cancer: A Real-World Study.Annals of surgical oncology · 2026Article
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Authors and funding
20 authors.
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Abstract
Background: Preoperative chemotherapy with cisplatin, fluorouracil, and docetaxel (DCF) is one of the neoadjuvant treatments for locally advanced esophageal squamous cell carcinoma (ESCC). However, the optimal number of DCF cycles remains unknown. This multi-institutional, randomized, phase II trial aimed to investigate the long-term survival outcomes of two versus three courses of DCF. Methods: A total of 180 patients with locally advanced ESCC from six institutions were randomly assigned to receive either two ( Results: Baseline characteristics were well balanced between the two groups. The 5-year overall survival (OS) and progression-free survival (PFS) rates for the three and two course groups were 70.7% vs. 63.8% (hazard ratio (HR) = 0.91, Conclusion: Two courses of preoperative DCF followed by radical esophagectomy can be one of the potential treatment strategies for locally advanced ESCC. Trial Registration: ClinicalTrials.gov identifier: UMIN 000015788.
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