ArticleFrontiers in oncology2025
Feasibility and safety of hepatic artery infusion chemotherapy via the distal transradial access for hepatocellular carcinoma.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Purpose: Hepatocellular carcinoma (HCC) remains a global health challenge, with hepatic artery infusion chemotherapy (HAIC) serving as a pivotal treatment for unresectable cases. Traditional transfemoral access (TFA) for HAIC is associated with significant limitations, including prolonged immobility, increased risk of deep vein thrombosis (DVT), and reduced quality of life. The distal transradial access (dTRA), emerging as a viable alternative in coronary and neurovascular interventions, offers potential advantages in HAIC. This study evaluates the feasibility, safety, and clinical outcomes of dTRA for HAIC in HCC patients, addressing the paucity of data in this specific application. Methods: A retrospective analysis was conducted on patients who underwent dTRA-HAIC procedures for HCC between November 2023 and December 2024. The puncture time, procedural time, incidence of distal radial artery occlusion (d-RAO) and access site complications (ASC) were used to evaluate the treatment efficacy in the patients. Univariate and multivariate logistic regression analysis was performed to identify predictive factors associated with d-RAO development. Results: The mean puncture time was 3.5 minutes (3-4.25 minutes), with a distal radial artery diameter of 1.96 ± 0.16 mm. The mean catheter indwelling time for mFOLFOX-HAIC and Ralox-HAIC were 2375 minutes (1715-3276 minutes) and 410 minutes (276, 544 minutes), respectively. Early d-RAO rates were 25.4% on postoperative day 1, declining to 20.6% at 6 months. Multivariate analysis identified preoperative D-dimer levels (p < 0.05) as significant risk factors for early d-RAO in one-month after operation. Multiple punctures may be associated with a high risk of d-RAO. No severe bleeding, hematoma, or pseudoaneurysm occurred. Conclusion: dTRA for HAIC demonstrates high technical feasibility and acceptable safety, representing a promising alternative to TFA. Preoperative D-dimer screening and limitations on repeated punctures may optimize outcomes. Larger multicenter studies are warranted to validate these findings and refine patient selection criteria.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.