Evidence map›Paper›PMID 41199839›Full record

ArticleFrontiers in oncology2025

An analysis of the distribution of bone and soft tissue sarcoma diagnoses and their disparities in Southwest Germany: a multicenter approach.

Branko Calukovic, Katrin Benzler, Mary E Carter, Adrien Daigeler, Johannes T Thiel, Jens Jakob, Bernd Kasper, Gerlinde Egerer, Leonidas Apostolidis, David Braig and 5 more

Erratum issuedAbstract read
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Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Branko CalukovicDepartment of Internal Medicine VIII - Medical Oncology and Pneumology, Medical University Hospital Tübingen, Tübingen, Germany.
Katrin BenzlerDepartment of Internal Medicine VIII - Medical Oncology and Pneumology, Medical University Hospital Tübingen, Tübingen, Germany.
Mary E CarterDepartment of Internal Medicine VIII - Medical Oncology and Pneumology, Medical University Hospital Tübingen, Tübingen, Germany.
Adrien DaigelerCenter for Soft Tissue Sarcomas, GIST and Bone Tumors (ZWS) of the University Hospital Tübingen and the Comprehensive Cancer Center (CCC) Tübingen-Stuttgart, Tübingen, Germany.
Johannes T ThielCenter for Soft Tissue Sarcomas, GIST and Bone Tumors (ZWS) of the University Hospital Tübingen and the Comprehensive Cancer Center (CCC) Tübingen-Stuttgart, Tübingen, Germany.
Jens JakobSarcoma Unit, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.
Bernd KasperSarcoma Unit, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.
Gerlinde EgererSarcoma Center Heidelberg, Heidelberg, Germany.
Leonidas ApostolidisSarcoma Center Heidelberg, Heidelberg, Germany.
David BraigSarcoma Center of the Comprehensive Cancer Center Freiburg (CCCF), Freiburg, Germany.
Simone HettmerSarcoma Center of the Comprehensive Cancer Center Freiburg (CCCF), Freiburg, Germany.
Claudia BlattmannSarcoma Center Stuttgart Cancer Center (SCC), Klinikum Stuttgart, Stuttgart, Germany.
Markus KnottStuttgart Cancer Center - Tumorzentrum Eva Mayr-Stihl, Klinikum Stuttgart, Stuttgart, Germany.
Lars ZenderDepartment of Internal Medicine VIII - Medical Oncology and Pneumology, Medical University Hospital Tübingen, Tübingen, Germany.
Christoph K W DeinzerDepartment of Internal Medicine VIII - Medical Oncology and Pneumology, Medical University Hospital Tübingen, Tübingen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Sarcoma is a rare and highly heterogeneous family of mesenchymal tumors. The experience and interdisciplinary approach of specialized high-volume sarcoma centers has a significant impact on disease treatment and outcome for patients. The aim of this retrospective, real-world, multicenter study was to evaluate geographic distribution of sarcoma cases in Southwest Germany and visually depict possible underrepresented areas of sarcoma primary diagnoses. Such descriptive information may indirectly guide future referral patterns and outreach activities of specialized sarcoma centers. Methods: The absolute number and incidence of sarcoma patients obtained from the Baden-Württemberg Cancer Registry were compared with the data from five individual, high-volume, specialized sarcoma centers. Furthermore, we used a "White-Spot Analysis" as a novel cost-effective approach in epidemiological and public health research for analyzing health care coverage in sarcoma care. Results: A total of 4,087 sarcoma patients living in the German Federal State of Baden-Württemberg between 2019 and 2022 were included in this study. Of these, 1,650 patients (40%) were treated primarily in specialized sarcoma centers whilst 2,437 patients (60%) received treatment for sarcoma outside of the five main high-volume centers, in underrepresented areas identified through White-Spot Analysis. The sarcoma incidence in Baden-Württemberg was calculated with our data to be 9.18/100,000 inhabitants per year. Discussion: In future, the access to high-volume centers needs to be facilitated in order to minimize the observed discrepancies between treatment in specialized sarcoma centers and low-volume centers in Southwest Germany. Our analysis highlights such discrepancies and may support future efforts to improve outcomes for sarcoma patients.

Indexed as

bone sarcomacancer registrygeographic disparitiesreal world datasoft tissue sarcomaspecialized sarcoma centerwhite-spot analysis

Identifiers

PMID41199839
PMCPMC12586119

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.