ArticleEnvironmental epigenetics2025
Redundancy, noise, and plasticity: repetitive DNA as an epigenetic intelligence backbone of inflammatory regulation.
Article in Environmental epigenetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundRepetitive DNA elements such as LINE1 have been proposed to support a redundant distributed, adaptive layer of gene regulation, contributing to "Epigenetic Intelligence" (EI). However, empirical evidence for their role in modulating inflammatory responses to environmental exposures remains limited.
objectivesWe investigated whether the association of PM with an aerodynamic diameter ≤10 µm (PM
methodsWe analyzed data from the SPHERE cohort (
resultsThe interaction between PM₁₀ exposure and LINE1 methylation was statistically supported (EDF ≈ 4.45,
conclusionsOur findings were coherent with the concept of EI. LINE1 methylation modulates the inflammatory response to environmental stressors, possibly acting as an adaptive epigenetic filter that buffers weak or transient signals. This distributed regulatory capacity may be critical for immune homeostasis under the dynamic environmental challenge.
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