Evidence map›Paper›PMID 41199776›Full record

SynthesisWellcome open research2023

Model systems informing mechanisms and drug discovery: a review of

Jonathan Meyrick, Renae J Stefanetti, Linda Errington, Robert McFarland, Gráinne S Gorman, Nichola Z Lax

Abstract readSystematic Review
In one paragraph

Synthesis in Wellcome open research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan MeyrickWellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, UK, Newcastle upon Tyne, NE24HH, UK.
Renae J StefanettiWellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, UK, Newcastle upon Tyne, NE24HH, UK.ORCID https://orcid.org/0000-0001-6402-6435
Linda ErringtonFaculty of Medical Sciences, Newcastle University, UK, Newcastle upon Tyne, NE24HH, UK.
Robert McFarlandWellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, UK, Newcastle upon Tyne, NE24HH, UK.
Gráinne S GormanWellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, UK, Newcastle upon Tyne, NE24HH, UK.
Nichola Z LaxWellcome Centre for Mitochondrial Research, Faculty of Medical Sciences, Newcastle University, UK, Newcastle upon Tyne, NE24HH, UK.

Funding

Wellcome Trust
6 · The paper itself

Abstract

Introduction: Pathogenic variants in the gene encoding the catalytic subunit of DNA polymerase gamma ( Methods: Four databases were searched from inception to May 31 Results: A total of 55 articles, including seven model organisms (Human, yeast [ Discussion: While some evidence is available to support the ability of PROSPERO registration: CRD42021234883.

Indexed as

epilepsymitochondriamtDNAneurological manifestationsPOLGpreclinical

Identifiers

PMID41199776
PMCPMC12586980

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.