Evidence map›Paper›PMID 41199671›Full record

ArticleAdvanced healthcare materials2026

Characterization of Microplastics in Human Gastric Cancer and Control Tissues and Analysis of Associated Genetic Features.

Liqiao Chen, Jialin Li, Yan Wu, Han Bao, Xuesong Yang, Guoqing Lv, Ke Ji, Ji Zhang, Xiaojiang Wu, Kai Zhou and 4 more

Abstract read
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Liqiao ChenKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Jialin LiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Yan WuDepartment of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital & Institute, Beijing, 100142, China.
Han BaoPeking University First Hospital, Beijing, 100034, China.
Xuesong YangDepartment of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Guoqing LvDepartment of Gastrointestinal Surgery, Peking University Shenzhen Hospital, Shenzhen, 518036, China.
Ke JiKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Ji ZhangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Xiaojiang WuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Kai ZhouKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Jieli XuKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Jiatian TangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.
Xiyuan HanDepartment of general surgery, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
Anqiang WangKey Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Center of Gastrointestinal Cancer, Peking University Cancer Hospital and Institute, Beijing, 100142, China.ORCID https://orcid.org/0009-0000-0178-9769

Funding

Beijing Physician Scientist Training Project BJPSTP-2025-11Clinical Medicine Plus X-Young Scholars Project, Peking University, the Fundamental Research Funds for the Central Universities PKU2024LCXQ022Clinical Research Fund for Distinguished Young Scholars of Peking University Cancer Hospital QNJJ202306Clinical Research Fund for Distinguished Young Scholars of Peking University Cancer Hospital QNJJ202415Science Foundation of Peking University Cancer Hospital PY202329
6 · The paper itself

Abstract

The presence of microplastics in the human body has been widely confirmed. This study aimed to characterize the presence of microplastics in human gastric tissue and explore the relationship between microplastic exposure and gastric cancer risk, as well as the potential underlying molecular mechanisms. Microplastics present in human gastric tissues are characterized using three methods. Following this, the relationship between microplastic exposure and the development of gastric cancer, as well as the potential underlying molecular mechanisms, is explored using clinical case data and transcriptome sequencing. Microplastics are widely present in human gastric tissues, with a significantly higher microplastic load observed in gastric tumor tissues than para-tumor and normal gastric tissues. Furthermore, a high microplastic load is significantly associated with lymph node metastasis in patients with gastric cancer. A high microplastic load leads to significant enrichment of biological processes and signaling pathways, such as cytotoxicity and oxidative stress. Additionally, a high microplastic load is associated with significant upregulation of genes associated with malignant disease, which is significantly associated with poor prognosis in patients with gastric cancer. Microplastic exposure may be a potential risk factor for the onset of gastric cancer.

Indexed as

MicroplasticsStomach NeoplasmsFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedTranscriptomeMicroplasticscharacterizationgastric cancermicroplasticstranscriptome sequencing

Identifiers

PMID41199671
PMCPMC12988576

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.