ArticleRenal failure2025
Single-cell immune landscape of acute kidney injury after cardiac surgery with cardiopulmonary bypass.
Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Perioperative immune dynamics during cardiopulmonary bypass and association with major adverse postoperative events.Frontiers in cardiovascular medicine · 2026Article
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Authors and funding
12 authors.
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Abstract
objectivesAcute kidney injury (AKI) occurs in 19-42% of patients with cardiac surgery under cardiopulmonary bypass (CPB). Clarifying their landscape of immune cells may help discover the mechanisms and thus the treatment and preventive strategies.
methodsThis prospective, single center study recruited adult patients scheduled for cardiac surgery. The primary outcome was AKI. Blood samples were harvested from the central vein for single-cell RNA sequencing, flow cytometry and protein microarrays to characterize the landscape of immune cells. Here we compared the single-cell RNA sequencing of 42,362 immune cells in the blood of 4 patients before and after cardiac surgery, depending on whether they experienced AKI or not.
resultsWe observed an increased degree of stronger activation and cytotoxicity of CD8
conclusionsTo our knowledge, this is the first prospective study to integrate single-cell RNA-seq, flow cytometry, and protein microarray in cardiac surgery-related AKI. Our analysis identified distinct immune cells and identified key biomarkers, including CD69, CD28, CCL5, ICAM1, IL-16 and MIF as candidate pathway.
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