Evidence map›Paper›PMID 41199531›Full record

ArticleJournal of pediatric gastroenterology and nutrition2026

Disease activity classification based on routinely collected blood tests in a prospective paediatric inflammatory bowel disease inception cohort.

Rona Lujan, Oren Ledder, Dotan Yogev, Raffi Lev-Tzion, Esther Orlanski-Meyer, Shira Yuval Bar-Asher, Ibrahim Shamasnah, Eyal Shteyer, Leora Gotesdyner, Mohammad Shawar and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Rona LujanJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID https://orcid.org/0000-0002-8449-1585
Oren LedderJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Dotan YogevJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Raffi Lev-TzionJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Esther Orlanski-MeyerJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Shira Yuval Bar-AsherJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Ibrahim ShamasnahJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Eyal ShteyerJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Leora GotesdynerJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Mohammad ShawarJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Elena FeldmanJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Gabriella AschkenasyJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Anna LevJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.
Dan TurnerJuliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem, Israel.

Funding

None
6 · The paper itself

Abstract

We have shown that disease-activity clusters derived from routine blood tests in administrative data predicted disease outcomes in Crohn's disease (CD). We aimed to validate these findings on a prospective inception cohort. Hierarchical clustering grouped children newly diagnosed with CD by similarities in diagnostic blood tests and fecal calprotectin and ordered by median laboratory values. The clusters were then validated against constructs of disease activity (weighted pediatric Crohn's disease activity index, physician global assessment, and simple endoscopic score [SES]-CD), and by their ability to predict disease course. Among 147 children with CD, three clusters were formed (mild, moderate, and severe with progressing worsening of laboratory values). A stepwise increase was observed in disease-activity constructs (e.g., median SES-CD 8 [3-12], 14 [8-18], 16 [8-26]; p < 0.001). Higher cluster severity was associated with a complicated-disease-course (vs. mild: hazard ratio 2.68; 95% confidence interval 1.19-6.05). Clustering routinely collected blood tests can reflect disease activity in CD and predict disease course.

Indexed as

Crohn DiseaseAdolescentBiomarkersChildChild, PreschoolCluster AnalysisDisease ProgressionFecesFemaleHematologic TestsHumansLeukocyte L1 Antigen ComplexMaleProspective StudiesSeverity of Illness IndexBiomarkersLeukocyte L1 Antigen ComplexCrohn's diseasehierarchical clusteringreal‐world data

Identifiers

PMID41199531
PMCPMC12780479

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.