Evidence map›Paper›PMID 41199470›Full record

Trial reportCNS neuroscience & therapeutics2025

Fornix Mediates Information Propagation in Brain Networks Following DLPFC-Targeted rTMS in Alzheimer's Disease: A Randomized Controlled Trial.

Yuxuan Shao, Lin Liu, Shuxiang Zhu, Ziyan Zhu, Pan Wang, Bharat B Biswal, Hua Lin

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in CNS neuroscience & therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yuxuan ShaoDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Lin LiuThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Shuxiang ZhuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Ziyan ZhuDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.
Pan WangThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.
Bharat B BiswalThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, Center for Information in Medicine, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0002-3710-3500
Hua LinDepartment of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.

Funding

Capital's Funds for Health Improvement and Research CFH2022-2-2014National Key R&D Program of China 2022YFC2402205National Natural Science Foundation of China 51977205National Natural Science Foundation of China NSFC62171101National Natural Science Foundation of China NSFC62401106NSFC Projects of International Cooperation and Exchanges NSFC-AF 82211530041Sichuan Science and Technology Program 2024NSFSC1661
6 · The paper itself

Abstract

aimsRepetitive transcranial magnetic stimulation (rTMS) could improve the clinical manifestations in Alzheimer's disease (AD), but its impact on deep brain tissue related to memory remains unclear. This study explored whether rTMS targeting cortical gray matter could regulate the white matter (WM) and exert modulatory effects on the network through WM bundles.

methodsSeventy-three AD patients underwent 14-day rTMS over the left dorsolateral prefrontal cortex (44 real, 25 sham). Granger causality analysis assessed changes in effective connectivity (EC) between the fornix and whole-brain voxels. Furthermore, the effects of rTMS treatment on fiber tracking parameters were analyzed.

resultsAfter rTMS therapy, patients with AD showed increased EC based on fornix in the real-stimulation group. Functional network projections indicated that these clusters belonged to the frontoparietal network, the somatomotor network, as well as three white matter networks. Additionally, increased EC associated with fornix exhibited lateralization on the right side. Diffusion tensor imaging results showed no significant differences after the 14-day rTMS treatment.

conclusionIn conclusion, a 14-day rTMS treatment in AD could regulate fornical function by increasing cortical-fornix EC, indicating neuroplasticity changes in response to therapy.

trial registrationChinese Clinical Trial Registry (https://www.chictr.org.cn/index.html; ChiCTR2200062564).

Indexed as

Alzheimer DiseaseDorsolateral Prefrontal CortexFornix, BrainNerve NetTranscranial Magnetic StimulationAgedAged, 80 and overDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedNeural PathwaysWhite MatterAlzheimer's diseaseeffective connectivityfornixrepetitive transcranial magnetic stimulationwhite matter

Identifiers

PMID41199470
PMCPMC12592100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.