ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
SV2B Promotes the Progression of TFE3-Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF-κB Subunits.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Activation of SV2B Inhibits Matrix-Stiffness-Induced Tumorigenesis and EMT in Glioma via FAK/PI3K/AKT Signaling Pathway.Oncology and therapy · 2026Article
- SV2B Promotes the Progression of TFE3-Rearranged Renal Cell Carcinoma by Interacting with HERC2 to Impede the Degradation of NF-κB Subunits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
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Authors and funding
14 authors.
Funding
Abstract
TFE3-rearranged renal cell carcinoma (TFE3-RCC) represents an aggressive subtype of renal cancer characterized by a poor prognosis, yet lacking clearly defined diagnostic and therapeutic targets. Here, the study demonstrates that synaptic vesicle protein 2B (SV2B) is a potential diagnostic marker and therapeutic target for TFE3-RCC. SV2B, identified as a TFE3 target gene, is significantly upregulated in TFE3-RCC and displays high diagnostic accuracy for this subtype. Functionally, SV2B enhances the proliferation, migration, and invasion of TFE3-RCC cells. Mechanistically, SV2B competes with RELA/NFKB1 for binding to the E3 ligase HERC2, preventing their degradation and activating the NF-κB pathway. The drug padsevonil, targeting SV2B, selectively inhibits the growth of TFE3-RCC cells and organoids, similar to the NF-κB inhibitor Withaferin A. Clinically, RELA/NFKB1 expression positively correlates with SV2B levels but negatively with HERC2 expression, confirming the activation of TFE3-SV2B-NF-κB axis in TFE3-RCC. These findings establish SV2B as a novel diagnostic biomarker for TFE3-RCC and validate SV2B-NF-κB signaling as a therapeutic target, providing potential strategies for managing TFE3-RCC.
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Registered trials
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