Trial reportBMC psychiatry2025
Impact of anxiety, depression and online mindfulness on IBD patients' quality of life: a web-based cross-sectional survey and randomized pilot study.
Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04939948 (Multi-factor Analysis of Psychological Disorders in Patients With Inflammatory Bowel Disease), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multi-factor Analysis of Psychological Disorders in Patients With Inflammatory Bowel Disease
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundIndividuals with Inflammatory Bowel Disease (IBD) often suffer from psychological comorbidities, including symptoms of anxiety and depression, which contribute to a substantial impairment in quality of life (QOL). The potential benefits of online mindfulness interventions for IBD remain unexplored.
objectiveStudy 1 (cross-sectional survey): To establish correlations between the severity of depression and anxiety and the QOL in IBD patients. Study 2 (pilot study): To evaluate the feasibility and preliminary effects of a mobile-delivered mindfulness intervention on psychological symptoms and QOL/sleep quality.
methodsStudy 1: Anxiety, depression and QOL were measured using the Generalized Anxiety Disorder-7 (GAD-7), Patient Health Questionnaire-9 (PHQ-9), and Short Health Scale (SHS) respectively. They were assessed in 484 IBD patients. Regression analyses determined associations. Study 2: A randomized parallel design tested the Online MINdfulness-based stress reduction with Daily EXercise (MINDEX) program vs an active control (IBD education video) over 2 months. Sleep quality was measured using Pittsburgh Sleep Quality Index (PSQI). Feasibility was assessed via retention (30/36 intervention vs. 22/36 control completers) and all completion rates (25%); Preliminary effects via GAD-7/PHQ-9/SHS/PSQI changes.
resultsStudy 1: More than 80% of the patients had severe anxiety or depression. The study revealed a significant association between increased GAD-7 scores and SHS scores, with an R2 of 0.43 and coefficient of 12.6 (95% CI 9.4–15.7) for UC (Ulcerative Colitis) and R2 of 0.27 with a coefficient of 10.4 (95% CI 8.8–12.1) for CD (Crohn’s Disease). Similarly, higher PHQ-9 scores correlated significantly with higher SHS scores, with an R2 of 0.37 and a coefficient of 9.2 (95% CI 6.5–11.8) for UC, and an R2 of 0.22 with a coefficient of 7.2 (95% CI 5.9–8.6) for CD. Study 2: 30 MINDEX patients completed the intervention, and 22 control patients completed the control program. At two-month follow-up, no statistically significant differences were observed in GAD-7, PHQ-9, SHS or PSAI scores between the MINDEX group and the control group (0.052 < P < 0.908).
conclusionsStudy 1: Our findings indicate strong associations between psychological symptoms and QOL in IBD, while causal relationships require Longitudinal investigation. Study 2: While feasibility to implement this pilot trial found no significant short-term benefits of MINDEX on anxiety, depression, QOL, or PSQI over the 2-month study period. Larger trials with longer follow-up are needed to evaluate efficacy.
trial registrationClinicalTrials.gov NCT04939948, Clinical Trial Registry June 17, 2021.
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