Observational studyBMC pulmonary medicine2025
Pulmonary function in non-hospitalized adults and children after mild COVID-19: a single-centre prospective cohort study.
Observational study in BMC pulmonary medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06318208 (Pulmonary Function in Non-hospitalized Adults and Children After Mild COVID-19), which is not on this map. Not yet cited in PubMed.
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Pulmonary Function in Non-hospitalized Adults and Children After Mild COVID-19
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0 citing papers in PubMed.
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the majority of patients suffering from COVID-19 (coronavirus disease 2019) did not require hospitalization, data on the persistence of pulmonary sequelae after a mild SARS-CoV-2 (severe acute respiratory disease coronavirus 2) infection in patients without pre-existing respiratory diseases are virtually missing.
methodsPulmonary function (spirometry, diffusion capacity for carbon monoxide (DLCO), and lung clearance index (LCI)) was assessed 4-12 weeks after SARS-CoV-2 infection in non-hospitalized patients aged 6-60 years. Acute and persisting COVID-19-related respiratory symptoms were ascertained, and the presence of other acute respiratory infection pathogens was checked via a multiplex-PCR approach from pharyngeal swabs. Participants with impaired lung function underwent a follow-up examination 3 months later. To complement the initial analysis, a retrospective z-score analysis of lung function parameters was conducted.
results110 patients (90 adults, 20 children) were included. In 45 adults (50%) and 17 children (85%), at least one pulmonary function test indicated an impaired lung function, particularly the LCI. Despite overall improvement between baseline and follow-up, 9 of 13 (69.2%) children and 35 of 42 (83.3%) adults with initial impairment still showed abnormal values about 5 months post SARS-CoV-2 infection. Specific respiratory symptoms were linked to lower spirometry and DLCO values. In 25 patients (40.3%) with abnormal lung function, and in 20 participants (43.5%) with normal pulmonary function, pathogens were detected at t
conclusionCritical pulmonary impairment after mild COVID-19 is rarely detected by spirometry and DLCO but may affect the LCI. Within 3 months, impaired pulmonary function improved in most patients. Children were less affected by severe pulmonary sequelae and respiratory complaints than adults. Complaints like dyspnoea or chest pain may be an early indicator of lung function impairment, suggesting that further diagnostic tests for treatable post-COVID-19 complications may be needed. Additionally, PCR-based screening for additional respiratory pathogens may help avoid misinterpretation of lung function results post SARS-CoV-2 infection.
trial registrationRetrospectively registered in ClinicalTrials.gov (ID NCT06318208) and German Clinical Trials Register (ID DRKS00030025).
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