Evidence map›Paper›PMID 41198969›Full record

ArticleNature cancer2026

Spatiotemporal control of SMARCA5 by a MAPK-RUNX1 axis distinguishes mutant KRAS-driven pancreatic malignancy from tissue regeneration.

Jing Han, Xiaoman Lu, Mengmeng Guo, Ruizhe He, Meilian Zhuo, Saisai Wang, Yong Li, Xiangzheng Liu, Di Zou, Jiacheng Wang and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jing HanState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0009-0004-5023-1912
Xiaoman LuState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Mengmeng GuoState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Ruizhe HeDepartment of General Surgery, Peking Union Medical College Hospital, Beijing, China.
Meilian ZhuoState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Saisai WangState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Yong LiState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Xiangzheng LiuState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Di ZouState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Jiacheng WangSchool of Life Sciences, Tsinghua University, Beijing, China.
Jiangjiao MaoState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Qian ChenState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China.
Xia WangSchool of Pharmaceutical Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0001-7081-1480
Junya PengState Key Laboratory of Complex Severe and Rare Diseases, Beijing, China.
Wei XieSchool of Life Sciences, Tsinghua University, Beijing, China.ORCID http://orcid.org/0000-0003-2126-3849
Charles J DavidState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China. cdavid@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-1257-8198
Mo ChenState Key Laboratory of Molecular Oncology, School of Basic Medical Sciences, Tsinghua University, Beijing, China. mochen@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0002-6647-8483

Funding

Beijing Municipal Science and Technology Commission Z231100007223008National Natural Science Foundation of China (National Science Foundation of China) 20231100054National Natural Science Foundation of China (National Science Foundation of China) 92068114
6 · The paper itself

Abstract

Acute pancreatitis-induced acinar-to-ductal metaplasia involves global chromatin remodeling and contributes to normal tissue regeneration. Oncogenic KRAS hijacks this process to promote PDAC formation. Here we show that regeneration and KRAS

Indexed as

Carcinoma, Pancreatic DuctalChromosomal Proteins, Non-HistoneCore Binding Factor Alpha 2 SubunitPancreatic NeoplasmsProto-Oncogene Proteins p21(ras)RegenerationAdenosine TriphosphatasesAnimalsChromatin Assembly and DisassemblyHumansMAP Kinase Signaling SystemMiceMutationAdenosine TriphosphatasesChromosomal Proteins, Non-HistoneCore Binding Factor Alpha 2 SubunitKRAS protein, humanProto-Oncogene Proteins p21(ras)RUNX1 protein, humanSMARCA5 protein, human

Identifiers

PMID41198969

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.