Evidence map›Paper›PMID 41198899›Full record

ArticleNature neuroscience2026

Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer's disease.

João Pedro Ferrari-Souza, Guilherme Povala, Nesrine Rahmouni, Bruna Bellaver, Pamela C L Ferreira, Marco Antônio De Bastiani, Douglas T Leffa, Firoza Z Lussier, Cristiano S Aguzzoli, Wagner S Brum and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Article
  2. Article
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  4. Integration of TSPO PET and fluid biomarkers to assess neuroinflammation in Parkinson's disease.European journal of nuclear medicine and molecular imaging · 2026
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Astrocyte-driven multicellular mechanisms of CNS repair and cerebroprotection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
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  12. Review
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  14. Observational
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

João Pedro Ferrari-Souza *Graduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID http://orcid.org/0000-0003-2183-1551
Guilherme Povala *Department of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2023-6569
Nesrine Rahmouni *Translational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
Bruna BellaverDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-2212-3373
Pamela C L FerreiraDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0003-2134-9829
Marco Antônio De BastianiGraduate Program in Biological Sciences: Pharmacology and Therapeutics, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Douglas T LeffaDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-4890-8451
Firoza Z LussierDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Cristiano S AguzzoliDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-7378-3830
Wagner S BrumGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Giovanna Carello-CollarGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Wyllians V BorelliGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Joseph TherriaultTranslational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
Arthur C MacedoTranslational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
Stijn ServaesTranslational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
Jenna StevensonTranslational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada.
Ilaria PolaDepartment of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Serge GauthierDepartment of Neurology and Neurosurgery, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Diogo O SouzaGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Lucas Porcello SchillingBrain Institute of Rio Grande do Sul, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil.
Mychael V LourencoInstitute of Medical Biochemistry Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.ORCID http://orcid.org/0000-0002-1078-0296
Gallen Triana-BaltzerPrecision Measures, Johnson & Johnson, La Jolla, CA, USA.
Hartmuth C KolbEnigma Biomedical Group, Knoxville, TN, USA.
Andréa L BenedetDepartment of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Dana L TudorascuDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0003-3930-4354
Kaj BlennowDepartment of Psychiatry and Neurochemistry, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0002-1890-4193
Sterling C JohnsonWisconsin Alzheimer's Disease Research Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA.ORCID http://orcid.org/0000-0002-8501-545X
Tharick A PascoalDepartment of Psychiatry, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9057-8014
Pedro Rosa-NetoTranslational Neuroimaging Laboratory, Montreal Neurological Institute, Montreal, Quebec, Canada. pedro.rosa@mcgill.ca.ORCID http://orcid.org/0000-0001-9116-1376
Eduardo R ZimmerGraduate Program in Biological Sciences: Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. eduardo.zimmer@hmv.org.br.ORCID http://orcid.org/0000-0002-5349-0053

Funding

Longitudinal multicenter head-to-head harmonization of tau PET tracersR01AG073267 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAKER, SUZANNE L, PASCOAL, THARICK · 2021 to 2025
$41.1M
Wisconsin Registry for Alzheimer's Prevention: Sex Differences in DNA MethylationR01AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Nathaniel Ark Chin, Sterling C Johnson · 2007 to 2026
$35.6M
Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5M
The Longitudinal Course of Neural Function and Amyloid in People At Risk for ADR01AG021155 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Sterling C Johnson · 2004 to 2026
$27.0M
Wisconsin Registry for Alzheimer's PreventionRF1AG027161 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI JOHNSON, STERLING C · 2018 to 2018
$18.8M
Head-to-head comparisons of high-performance plasma phospho-tau epitopes for the detection of Alzheimer's diseaseR01AG075336 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Tharick Pascoal · 2022 to 2026
$3.7M
The effects of iron on oxidative stress and Alzheimer's biomarkers in amyloid-positive and negative elderly normalR01AG068398 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI CHIANG, GLORIA CHIA-YI · 2020 to 2024
$2.8M
Alzheimer's Association 24AACSF-1200375Alzheimer's Association 24AARFD-1243899Alzheimer's Association AACSF-D 22-928689Alzheimer's Association AARFD-22-923814Alzheimer's Association AARFD-22-974627Alzheimer's Association AARFD-23-1148735Alzheimer's Association AARGD-21-850670, AACSFD-22-928689, AARFD-23-1148735, and BFECAA2024Alzheimer's Association ADSF-21-831376-C, ADSF-21-831381-C, ADSF-21-831377-C, and ADSF-24-1284328-CAlzheimer's Association NIRG-12-92090 and NIRP-12-259245Alzheimer's Association ZEN-21-848495 and SG-23-1038904 QCAlzheimer's Drug Discovery Foundation (ADDF) 201809-2016862Alzheimer's Drug Discovery Foundation (ADDF) RDAPB-201809-2016615EU Joint Programme - Neurodegenerative Disease Research (Programi i Përbashkët i BE-së për Kërkimet mbi Sëmundjet Neuro-degjeneruese) JPND2019-466-236EU Joint Programme - Neurodegenerative Disease Research (Programi i Përbashkët i BE-së për Kërkimet mbi Sëmundjet Neuro-degjeneruese) JPND2021-00694Fonds de Recherche du Québec - Santé (Fonds de la recherche en sante du Quebec) 2020-VICO-279314 and 2024-VICO-356138Gouvernement du Canada | Canadian Institutes of Health Research (Instituts de Recherche en Santé du Canada) MOP-11-51-31; RFN 152985, 159815, and 162303Ministry of Science, Technology and Innovation | Conselho Nacional de Desenvolvimento Científico e Tecnológico (National Council for Scientific and Technological Development) 200691/2021-0NIA NIH HHS P30 AG062715NIA NIH HHS R01 AG021155NIA NIH HHS R01 AG027161NIA NIH HHS R01 AG068398NIA NIH HHS R01 AG073267NIA NIH HHS R01 AG075336NIA NIH HHS RF1 AG027161U.S. Department of Health & Human Services | National Institutes of Health (NIH) AG027161, AG021155, and AG062715U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG068398U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG075336 and R01AG073267Vetenskapsrådet (Swedish Research Council) 2017-00915 and 2022-00732Vetenskapsrådet (Swedish Research Council) 2023-00356, 2022-01018 and 2019-02397
6 · The paper itself

Abstract

Experimental evidence suggests that activated microglia induce astrocyte reactivity in neurodegenerative disorders, such as Alzheimer's disease (AD). In this study, we investigated the association between microglial activation and amyloid-β (Aβ) with reactive astrogliosis in individuals across the AD spectrum. We examined 101 individuals using positron emission tomography radiotracers to assess Aβ deposition ([

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAstrocytesMicrogliaAgedAged, 80 and overBrainFemaleHumansMaleMembrane GlycoproteinsMiddle AgedPhosphorylationPositron-Emission TomographyReceptors, Immunologictau ProteinsAmyloid beta-PeptidesMembrane GlycoproteinsReceptors, Immunologictau Proteins

Identifiers

PMID41198899
PMCPMC12779546

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.