ArticleNature neuroscience2025
Selective direct influence of motor cortex on limb muscle activity during naturalistic climbing in mice.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- A brain-wide, trial- and time-dependent deterministic drive synergizes with within-trial noise to time self-initiated actions.bioRxiv : the preprint server for biology · 2026Article
- Integrated approaches for investigating the neural bases of movement-highlights from the 34th Annual Meeting of the Society for the Neural Control of Movement.Journal of neurophysiology · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors.Nature communications · 2025Article
- Motor Cortical Output Integrates Distorted Proprioceptive Feedback.bioRxiv : the preprint server for biology · 2025Article
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7 authors.
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Abstract
When and how motor cortical output directly influences limb muscle activity through descending projections remain poorly resolved, impeding a mechanistic understanding of motor control. Here we addressed this in mice performing an ethologically inspired climbing behavior. We quantified the direct influence of forelimb primary motor cortex (caudal forelimb area) on muscles across the muscle activity states expressed during climbing. We found that the caudal forelimb area instructs muscle activity pattern by selectively activating certain muscles, while less frequently activating or suppressing their antagonists. From Neuropixels recordings, we identified linear combinations (components) of motor cortical activity that covary with these effects. These components differ partially from those that covary with muscle activity and differ almost completely from those that covary with kinematics. Collectively, our results reveal an instructive direct motor cortical influence on limb muscles that is selective within a motor behavior and reliant on a distinct neural activity subspace.
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