Evidence map›Paper›PMID 41198896›Full record

Observational studyCommunications biology2025

Neural and molecular changes during a mind-body reconceptualization, meditation, and open label placebo healing intervention.

Alex Jinich-Diamant, Sierra Simpson, Juan P Zuniga-Hertz, Ramamurthy Chitteti, Jan M Schilling, Jacqueline A Bonds, Laura Case, Andrei V Chernov, Joe Dispenza, Jacqueline Maree and 9 more

Erratum issued Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07738653 (Changes in Spatiotemporal Gait Parameters After a 5-Day Mindfulness Retreat), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07738653 nacompletednot on this map

Changes in Spatiotemporal Gait Parameters After a 5-Day Mindfulness Retreat: A Pre-Post Pilot Study in Experienced Meditators

TypeinterventionalSponsorHospital Miguel ServetRan2023 to 2023Enrolled13ConditionsMindfulness, Gait BiomechanicsArmsMeditation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Alex Jinich-DiamantDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Sierra SimpsonDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Juan P Zuniga-HertzDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Ramamurthy ChittetiDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Jan M SchillingDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Jacqueline A BondsDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Laura CaseDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.ORCID http://orcid.org/0000-0003-3730-2451
Andrei V ChernovDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Joe DispenzaMetamorphosis LLC, Ranier, WA, USA.
Jacqueline MareeVitaMed Research, Palm Desert, CA, USA.
Natalia Esther Amkie StahlDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Michael LicameleDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Narin FazlalipourDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Swetha DevulapalliDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA.
Leonardo Christov-MooreInstitute for Advanced Consciousness Studies, Santa Monica, CA, USA.
Nicco ReggenteInstitute for Advanced Consciousness Studies, Santa Monica, CA, USA.ORCID http://orcid.org/0000-0002-0511-9962
Michelle A PoirierMetamorphosis LLC, Ranier, WA, USA.
Tobias Moeller-BertramVitaMed Research, Palm Desert, CA, USA.
Hemal H PatelDepartment of Anesthesiology, University of California San Diego, La Jolla, CA, USA. hepatel@health.ucsd.edu.ORCID http://orcid.org/0000-0001-6722-9625

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
BLRD VA IK6 BX005229NIGMS NIH HHS K12 GM068524
6 · The paper itself

Abstract

Mind-body interventions offer promising avenues for improving physical and mental health, yet the comprehensive biological effects of increasingly popular mind-body retreat interventions remain poorly understood. The neural and molecular effects of a 7-day retreat intervention combining meditation, reconceptualization, and open-label placebo healing rituals are investigated in an observational study on 20 healthy human participants randomly selected from 561 retreat participants. BOLD fMRI functional connectivity during rest and meditation and whole plasma proteomics, metabolomics, exosome-specific miRNA transcriptomics, and neurite growth and real-time metabolism cellular assays are compared pre- and post-intervention. Meditation decreases functional integration in the default mode (p = 0.00009) and salience networks (p = 0.000003) and decreases whole-brain modularity (p = 0.001). Compared to pre-intervention plasma, post plasma increases in vitro neurite outgrowth (p = 0.01), enhances glycolytic metabolism (p = 0.008), induces upregulation of BDNF (p = 0.001), inflammatory (p = 0.0001), anti-inflammatory (p = 0.03), and endogenous opioid (p = 0.03) pathways, and modulates tryptophan metabolism (p

Indexed as

BrainMeditationMind-Body TherapiesAdultFemaleHumansMagnetic Resonance ImagingMaleMicroRNAsMiddle AgedYoung AdultMicroRNAs

Identifiers

PMID41198896
PMCPMC12592435

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.