ArticleScientific reports2025
Vitamin D modulates gene expression in four major muscle tissues in Atlantic salmon.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Dietary Intake of 25-Hydroxy Vitamin D3 from First Feeding Improves Feed Efficiency and Modulates Hepatic Metabolic Transcriptome in Rainbow Trout.Marine biotechnology (New York, N.Y.) · 2026Article
- Dietary Vitamin D2 Is Less Potent Than Vitamin D3 at Maintaining or Restoring Structure and Metabolism of Skeletal Muscle and Heart in Male Rats.Molecular nutrition & food research · 2026Article
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Authors and funding
6 authors.
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Abstract
Vitamin D is essential to muscle health but could affect different muscle tissues in distinct ways. In humans, vitamin D is primarily synthesized in the skin via sun exposure but can also be obtained through ingesting foods that are fortified (e.g., milk) or naturally high in vitamin D (e.g., salmon). Like humans, salmon vitamin D content can vary considerably and can be altered through dietary consumption of vitamin D. We experimentally determined how vitamin D manipulation alters gene expression in four salmon muscle tissues: skeletal, craniofacial, smooth, and cardiac. Vitamin D induced changes in expression were exceptionally profound in the heart, where there were also several gene duplicates expressed unidirectionally. Five genes were differentially expressed in multiple muscles and many genes impacted by our vitamin D treatments in salmon show extensive evolutionary conservation as they are influenced by vitamin D titers in mammals, including humans. Salmon could provide a powerful model for understanding how variation in vitamin D impacts all vertebrates.
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Registered trials
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