ArticleScientific reports2025
Red cell distribution width and cerebral white matter hyperintensity.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Red cell distribution width (RDW) is an indicator of red blood cell size heterogeneity and may reflect underlying chronic hypoxemia or inflammation. While RDW has been associated with the prognosis of various pulmonary and cardiovascular diseases, its relevance in cerebrovascular disease remains underexplored. In this study, we evaluated the association between RDW and cerebral small vessel disease (cSVD). We evaluated consecutive health check-up participants who underwent brain MRI between January 2006 and December 2013. As subtypes of cSVD, white matter hyperintensity (WMH) was quantitatively assessed, while lacunes and cerebral microbleeds (CMBs) were evaluated qualitatively. RDW was measured from blood samples as part of the complete blood cell count. A total of 3,040 health check-up participants were evaluated (mean age: 56.3 years, male sex: 53.6%, mean body mass index: 24.16 kg/m2). In multivariable linear regression analysis, RDW was significantly associated with WMH volume after adjusting for confounders [β = 1.789, 95% confidence interval (CI): 0.115 to 3.463]. Age, systolic blood pressure, white blood cell and red blood cell counts were also associated with WMH volume, independent of RDW. On the other hand, lacunes and CMBs were not significantly associated with RDW after adjusting for confounders. RDW was associated with cSVD in health check-up participants. This association was observed exclusively with the WMH, while no significant relationship was found with lacunes or CMBs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.